PURPOSE: Repeated hepatic resections are not uncommon during the surgical management of liver tumors. Postoperative adhesions induced by hepatectomies can have a significant negative impact on subsequent surgeries. We recently developed a new hepatectomy-induced postoperative adhesion animal model to evaluate the anti-adhesion efficacy of commercially available sheet materials (Seprafilm(®) and Interceed(®)) and the recently reported hyaluronan-based in situ cross-linkable hydrogels. METHODS: The median lobe (ML) and the left lateral lobe (LLL) of the liver (approximately 70 % of the total liver) of 43 male Sprague-Dawley rats were resected based on the classical procedure; anti-adhesion materials were then applied. A relaparotomy was performed 1 week later to evaluate the adhesions and histopathological findings. RESULTS: The rats without the application of anti-adhesion materials (n = 14) showed the most severe adhesions (grade 3) between the cut surface of the liver and the small bowel or omentum. All the barrier materials produced slight anti-adhesion effects. Adhesions between the liver surface and the diaphragm and adhesions around the hepatic hilum were less severe, but were not remarkably reduced, by the anti-adhesion materials. CONCLUSION: We successfully established a new hepatectomy-induced animal adhesion model, which may be useful for the development of new anti-adhesion materials.
PURPOSE: Repeated hepatic resections are not uncommon during the surgical management of liver tumors. Postoperative adhesions induced by hepatectomies can have a significant negative impact on subsequent surgeries. We recently developed a new hepatectomy-induced postoperative adhesion animal model to evaluate the anti-adhesion efficacy of commercially available sheet materials (Seprafilm(®) and Interceed(®)) and the recently reported hyaluronan-based in situ cross-linkable hydrogels. METHODS: The median lobe (ML) and the left lateral lobe (LLL) of the liver (approximately 70 % of the total liver) of 43 male Sprague-Dawley rats were resected based on the classical procedure; anti-adhesion materials were then applied. A relaparotomy was performed 1 week later to evaluate the adhesions and histopathological findings. RESULTS: The rats without the application of anti-adhesion materials (n = 14) showed the most severe adhesions (grade 3) between the cut surface of the liver and the small bowel or omentum. All the barrier materials produced slight anti-adhesion effects. Adhesions between the liver surface and the diaphragm and adhesions around the hepatic hilum were less severe, but were not remarkably reduced, by the anti-adhesion materials. CONCLUSION: We successfully established a new hepatectomy-induced animal adhesion model, which may be useful for the development of new anti-adhesion materials.
Authors: Ershuai Zhang; Boyi Song; Yuanjie Shi; Hui Zhu; Xiangfei Han; Hong Du; Chengbiao Yang; Zhiqiang Cao Journal: Proc Natl Acad Sci U S A Date: 2020-11-30 Impact factor: 11.205
Authors: Yoshihiro Mise; Guillaume Passot; Xuemei Wang; Hsiang-Chun Chen; Steven Wei; Kristoffer W Brudvik; Thomas A Aloia; Claudius Conrad; Steven Y Huang; Jean-Nicolas Vauthey Journal: J Gastrointest Surg Date: 2016-04-12 Impact factor: 3.452
Authors: D Poehnert; L Grethe; L Maegel; D Jonigk; T Lippmann; A Kaltenborn; H Schrem; J Klempnauer; M Winny Journal: Int J Med Sci Date: 2016-06-30 Impact factor: 3.738