Literature DB >> 23497252

Synthesis and antimalarial bioassay of quinine - peptide conjugates.

Siva S Panda1, Mohamed A Ibrahim, Hasan Küçükbay, Marvin J Meyers, Francis M Sverdrup, Said A El-Feky, Alan R Katritzky.   

Abstract

Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52-95% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100 nm, similar to quinine.
© 2013 John Wiley & Sons A/S.

Entities:  

Keywords:  amino acid; chemical biology; drug design; peptide

Mesh：

Substances：

Year:  2013        PMID： 23497252     DOI： 10.1111/cbdd.12134

Source DB:  PubMed          Journal:  Chem Biol Drug Des        ISSN： 1747-0277            Impact factor:   2.817


  7 in total

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