Literature DB >> 23479275

[Pancreatic cancer in the elderly: guidelines and individualized therapy].

H Nieß1, A Kleespies, J Andrassy, S Pratschke, P Pratschke, M K Angele, M Guba, K-W Jauch, C J Bruns.   

Abstract

The considerable increase of the aged population in western civilisation within the next years will result in a rising incidence of pancreatic cancer. Until the year 2020 an increment of 20  % of patients beyond 65 years old can be anticipated. Therefore, the focus will be on management of old and geriatric surgical patients leading to strategical re-evaluation of surgical indications under critical consideration of feasibility and purpose. Even under modern interdisciplinary therapy concepts the prognosis of ductal adenocarcinoma of the pancreas remains poor with an overall 5-year survival rate of less than 5  %. The surgical resection is still considered as the only potential curative treatment option with extended life expectancy; however, it is technically demanding and furthermore associated with significant morbidity. In particular, the quality of surgery of the now interdisciplinary therapy of pancreatic cancer is markedly improved when performed at a high-volume centres. Until now only a few retrospective data analyses evaluating the perioperative and long-term outcome after pancreatic tumor resections in geriatric patients exist. The available results, however, support radical surgical procedures even beyond the age of 75 years.

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Year:  2013        PMID: 23479275     DOI: 10.1007/s00104-012-2455-y

Source DB:  PubMed          Journal:  Chirurg        ISSN: 0009-4722            Impact factor:   0.955


  36 in total

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Journal:  Ann Surg       Date:  2007-04       Impact factor: 12.969

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5.  Prognostic factors in periampullary and pancreatic tumor resection in elderly patients.

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Journal:  World J Surg       Date:  2006-11       Impact factor: 3.352

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Authors:  Taylor S Riall
Journal:  Adv Surg       Date:  2009

7.  Pancreatic or liver resection for malignancy is safe and effective for the elderly.

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Journal:  Ann Surg       Date:  1995-10       Impact factor: 12.969

8.  Pancreatic cancer: surgery is a feasible therapeutic option for elderly patients.

Authors:  Guy Lahat; Ronen Sever; Nir Lubezky; Ido Nachmany; Fabian Gerstenhaber; Menahem Ben-Haim; Richard Nakache; Josef Koriansky; Josef M Klausner
Journal:  World J Surg Oncol       Date:  2011-01-27       Impact factor: 2.754

Review 9.  Surgical strategies for treatment of malignant pancreatic tumors: extended, standard or local surgery?

Authors:  Matthias Glanemann; Baomin Shi; Feng Liang; Xiao-Gang Sun; Marcus Bahra; Dietmar Jacob; Ulf Neumann; Peter Neuhaus
Journal:  World J Surg Oncol       Date:  2008-11-12       Impact factor: 2.754

10.  Pancreaticoduodenectomy of pancreatic ductal adenocarcinoma in the elderly.

Authors:  Chang Moo Kang; Jun Young Kim; Gi Hong Choi; Kyung Sik Kim; Jin Sub Choi; Woo Jung Lee; Byong Ro Kim
Journal:  Yonsei Med J       Date:  2007-06-30       Impact factor: 2.759

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  4 in total

1.  [Pancreatic resection in the elderly : Is the risk justified?].

Authors:  K Feilhauer; R Hennig; S Lenz; J Köninger
Journal:  Chirurg       Date:  2015-07       Impact factor: 0.955

Review 2.  An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression.

Authors:  Aamir Ali Khan; Xinhui Liu; Xinlong Yan; Muhammad Tahir; Sakhawat Ali; Hua Huang
Journal:  Cancer Metastasis Rev       Date:  2021-01-10       Impact factor: 9.264

Review 3.  A Systematic Review of the Burden of Pancreatic Cancer in Europe: Real-World Impact on Survival, Quality of Life and Costs.

Authors:  A Carrato; A Falcone; M Ducreux; J W Valle; A Parnaby; K Djazouli; K Alnwick-Allu; A Hutchings; C Palaska; I Parthenaki
Journal:  J Gastrointest Cancer       Date:  2015-09

4.  Equal Efficacy and Safety Profile in Elderly Patients with Hepatocellular Carcinoma Receiving Palliative Treatment.

Authors:  Thorben W Fründt; Christian Casar; Johann von Felden; Ulrike Schöler; Maximilian Priebe; Jenny Kraczyk; Hannes Ahrend; Johannes Salamon; Gerhard Adam; Samuel Huber; Ansgar W Lohse; Henning Wege; Kornelius Schulze
Journal:  Cancers (Basel)       Date:  2022-02-01       Impact factor: 6.639

  4 in total

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