BACKGROUND: Diffusion tensor imaging (DTI) can be used to predict outcome following perinatal arterial ischemic stroke (PAIS), although little is known about white matter changes over time. METHODS: Infants with PAIS were serially scanned in the neonatal period (n = 15), at 3 mo (n = 16), and at 24 mo (n = 8). Fractional anisotropy (FA) values in five regions of interest (anterior and posterior limb of the internal capsule, corpus callosum, optic radiation, and posterior thalamic radiation) were obtained and compared with FA values of healthy controls and neurodevelopmental outcome. RESULTS: In the neonatal period, no differences in FA values were found. At 3 mo, the six infants who ultimately developed motor deficits showed lower FA values in all affected regions. Four infants developed a visual field defect and showed lower FA values in the affected optic radiation at 3 mo (0.22 vs. 0.29; P = 0.03). Finally, a correlation between FA values of the corpus callosum at 3 mo and the Griffiths developmental quotients was found (r = 0.66; P = 0.03). At 24 mo, a similar pattern was observed. CONCLUSION: Neonatal FA measurements may underestimate the extent of injury following PAIS. FA measurements at 3 mo could be considered a more reliable predictor of neurodevelopmental outcome and correlate with DTI findings at 24 mo.
BACKGROUND: Diffusion tensor imaging (DTI) can be used to predict outcome following perinatal arterial ischemic stroke (PAIS), although little is known about white matter changes over time. METHODS:Infants with PAIS were serially scanned in the neonatal period (n = 15), at 3 mo (n = 16), and at 24 mo (n = 8). Fractional anisotropy (FA) values in five regions of interest (anterior and posterior limb of the internal capsule, corpus callosum, optic radiation, and posterior thalamic radiation) were obtained and compared with FA values of healthy controls and neurodevelopmental outcome. RESULTS: In the neonatal period, no differences in FA values were found. At 3 mo, the six infants who ultimately developed motor deficits showed lower FA values in all affected regions. Four infants developed a visual field defect and showed lower FA values in the affected optic radiation at 3 mo (0.22 vs. 0.29; P = 0.03). Finally, a correlation between FA values of the corpus callosum at 3 mo and the Griffiths developmental quotients was found (r = 0.66; P = 0.03). At 24 mo, a similar pattern was observed. CONCLUSION: Neonatal FA measurements may underestimate the extent of injury following PAIS. FA measurements at 3 mo could be considered a more reliable predictor of neurodevelopmental outcome and correlate with DTI findings at 24 mo.
Authors: Andreia V Faria; Alexander Hoon; Elaine Stashinko; Xin Li; Hangyi Jiang; Ameneh Mashayekh; Kazi Akhter; John Hsu; Kenichi Oishi; Jiangyang Zhang; Michael I Miller; Peter C M van Zijl; Susumu Mori Journal: Neuroimage Date: 2010-11-05 Impact factor: 6.556
Authors: Laura Bassi; Daniela Ricci; Anna Volzone; Joanna M Allsop; Latha Srinivasan; Aakash Pai; Carmen Ribes; Luca A Ramenghi; Eugenio Mercuri; Fabio Mosca; A David Edwards; Frances M Cowan; Mary A Rutherford; Serena J Counsell Journal: Brain Date: 2008-02 Impact factor: 13.501
Authors: Elise Roze; Polly A Harris; Gareth Ball; Leire Zubiaurre Elorza; Rodrigo M Braga; Joanna M Allsop; Nazakat Merchant; Emma Porter; Tomoki Arichi; A David Edwards; Mary A Rutherford; Frances M Cowan; Serena J Counsell Journal: Neuroradiology Date: 2011-10-18 Impact factor: 2.804
Authors: Andrea M Kuczynski; Helen L Carlson; Catherine Lebel; Jacquie A Hodge; Sean P Dukelow; Jennifer A Semrau; Adam Kirton Journal: Hum Brain Mapp Date: 2017-02-08 Impact factor: 5.038
Authors: Markus Breu; Dominik Reisinger; Liangcheng Tao; Dan Wu; Yajing Zhang; Matthew D Budde; Ali Fatemi; Arvind P Pathak; Jiangyang Zhang Journal: Brain Struct Funct Date: 2019-04-22 Impact factor: 3.270
Authors: Andrea M Kuczynski; Sean P Dukelow; Jacquie A Hodge; Helen L Carlson; Catherine Lebel; Jennifer A Semrau; Adam Kirton Journal: Hum Brain Mapp Date: 2017-11-29 Impact factor: 5.038