BACKGROUND: The corpus callosum (CC) is a cerebral structure that reflects cognitive status in several neurological pathologies. Visual inspection of MRI has shown that hypoxic-ischemic encephalopathy(HIE) causes callosal damage. PRIMARY OBJECTIVE: To quantify the CC surface in a sample of patients with antecedents of HIE and a group of matched controls. RESEARCH DESIGN: Comparisons of CC measures among control subjects, mild HIE patients and moderateHIE patients as well as correlates of CC surface and neuropsychological performance. METHODS: Twenty-one adolescent patients with childhood antecedents of HIE were compared to 21 controls. ANALYZE software was used to semi-automatically measure the CC area. MAIN OUTCOMES AND RESULTS: Patients with moderate HIE showed corpus callosum reduction. The isthmus and genus were the most affected regions. Corpus callosum size correlated with cognitive function. CONCLUSIONS: Corpus callosum quantification provides new evidence of subtle residual deficits in subjects with HIE antecedents without apparent neurological sequelae.
BACKGROUND: The corpus callosum (CC) is a cerebral structure that reflects cognitive status in several neurological pathologies. Visual inspection of MRI has shown that hypoxic-ischemicencephalopathy(HIE) causes callosal damage. PRIMARY OBJECTIVE: To quantify the CC surface in a sample of patients with antecedents of HIE and a group of matched controls. RESEARCH DESIGN: Comparisons of CC measures among control subjects, mild HIEpatients and moderateHIE patients as well as correlates of CC surface and neuropsychological performance. METHODS: Twenty-one adolescent patients with childhood antecedents of HIE were compared to 21 controls. ANALYZE software was used to semi-automatically measure the CC area. MAIN OUTCOMES AND RESULTS:Patients with moderate HIE showed corpus callosum reduction. The isthmus and genus were the most affected regions. Corpus callosum size correlated with cognitive function. CONCLUSIONS: Corpus callosum quantification provides new evidence of subtle residual deficits in subjects with HIE antecedents without apparent neurological sequelae.
Authors: Ericka L Fink; A Panigrahy; R S B Clark; C R Fitz; D Landsittel; P M Kochanek; G Zuccoli Journal: Neurocrit Care Date: 2013-08 Impact factor: 3.210
Authors: K Klebermass-Schrehof; S Aumüller; K Goeral; K Vergesslich-Rothschild; R Fuiko; S Brandstetter; A Berger; B Jilma; N Haiden Journal: J Perinatol Date: 2016-12-15 Impact factor: 2.521
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Authors: Thomas Alderliesten; Linda S de Vries; Yara Khalil; Ingrid C van Haastert; Manon J N L Benders; Corine Koopman-Esseboom; Floris Groenendaal Journal: PLoS One Date: 2015-04-29 Impact factor: 3.240