Catarina Saiote1, Ellen Sutter, Annette Xenopoulos-Oddsson, Raghavendra Rao, Michael Georgieff, Kyle Rudser, Colleen Peyton, Douglas Dean, Ryan M McAdams, Bernadette Gillick. 1. Waisman Center (Drs Saiote, Sutter, Dean, and Gillick), Department of Pediatrics (Drs Dean, McAdams, and Gillick), and Department of Medical Physics (Dr Dean), University of Wisconsin-Madison, Madison, Wisconsin; Department of Rehabilitation Medicine (Dr Sutter and Ms Xenopoulos-Oddsson), Department of Pediatrics (Drs Rao and Georgieff), and Division of Biostatistics (Dr Rudser), University of Minnesota, Minneapolis, Minnesota; Department of Physical Therapy and Human Movement Sciences, Department of Pediatrics (Dr Peyton), Northwestern University, Chicago, Illinois.
Abstract
PURPOSE: Perinatal brain injury is a primary cause of cerebral palsy, a condition resulting in lifelong motor impairment. Infancy is an important period of motor system development, including development of the corticospinal tract (CST), the primary pathway for cortical movement control. The interaction between perinatal stroke recovery, CST organization, and resultant motor outcome in infants is not well understood. METHODS: Here, we present a protocol for multimodal longitudinal assessment of brain development and motor function following perinatal brain injury using transcranial magnetic stimulation and magnetic resonance imaging to noninvasively measure CST functional and structural integrity across multiple time points in infants 3 to 24 months of age. We will further assess the association between cortical excitability, integrity, and motor function. DISCUSSION: This protocol will identify bioindicators of motor outcome and neuroplasticity and subsequently inform early detection, diagnosis, and intervention strategies for infants with perinatal stroke, brain bleeds, and related diagnoses.
PURPOSE: Perinatal brain injury is a primary cause of cerebral palsy, a condition resulting in lifelong motor impairment. Infancy is an important period of motor system development, including development of the corticospinal tract (CST), the primary pathway for cortical movement control. The interaction between perinatal stroke recovery, CST organization, and resultant motor outcome in infants is not well understood. METHODS: Here, we present a protocol for multimodal longitudinal assessment of brain development and motor function following perinatal brain injury using transcranial magnetic stimulation and magnetic resonance imaging to noninvasively measure CST functional and structural integrity across multiple time points in infants 3 to 24 months of age. We will further assess the association between cortical excitability, integrity, and motor function. DISCUSSION: This protocol will identify bioindicators of motor outcome and neuroplasticity and subsequently inform early detection, diagnosis, and intervention strategies for infants with perinatal stroke, brain bleeds, and related diagnoses.
Authors: Iona Novak; Cathy Morgan; Lars Adde; James Blackman; Roslyn N Boyd; Janice Brunstrom-Hernandez; Giovanni Cioni; Diane Damiano; Johanna Darrah; Ann-Christin Eliasson; Linda S de Vries; Christa Einspieler; Michael Fahey; Darcy Fehlings; Donna M Ferriero; Linda Fetters; Simona Fiori; Hans Forssberg; Andrew M Gordon; Susan Greaves; Andrea Guzzetta; Mijna Hadders-Algra; Regina Harbourne; Angelina Kakooza-Mwesige; Petra Karlsson; Lena Krumlinde-Sundholm; Beatrice Latal; Alison Loughran-Fowlds; Nathalie Maitre; Sarah McIntyre; Garey Noritz; Lindsay Pennington; Domenico M Romeo; Roberta Shepherd; Alicia J Spittle; Marelle Thornton; Jane Valentine; Karen Walker; Robert White; Nadia Badawi Journal: JAMA Pediatr Date: 2017-09-01 Impact factor: 16.193
Authors: Vladimir Fonov; Alan C Evans; Kelly Botteron; C Robert Almli; Robert C McKinstry; D Louis Collins Journal: Neuroimage Date: 2010-07-23 Impact factor: 6.556