Literature DB >> 23475668

Identification of endogenous substrates of orphan cytochrome P450 enzymes through the use of untargeted metabolomics approaches.

Qian Cheng1, F Peter Guengerich.   

Abstract

Metabolomics provides an invaluable means to interrogate the function of "orphan" enzymes, i.e., those whose endogenous substrates are not known. Here we describe a high-performance liquid chromatography-coupled mass spectrometry (HPLC-MS)-based metabolomics approach to identify an endogenous substrate of an orphan cytochrome P450.

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Year:  2013        PMID： 23475668      PMCID： PMC3846702          DOI： 10.1007/978-1-62703-321-3_6

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  7 in total

Review 1.  Characterizing proteins of unknown function: orphan cytochrome p450 enzymes as a paradigm.

Authors:  F Peter Guengerich; Zhongmei Tang; S Giovanna Salamanca-Pinzón; Qian Cheng
Journal:  Mol Interv       Date:  2010-06

2.  XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification.

Authors:  Colin A Smith; Elizabeth J Want; Grace O'Maille; Ruben Abagyan; Gary Siuzdak
Journal:  Anal Chem       Date:  2006-02-01       Impact factor: 6.986

3.  Cyclization of a cellular dipentaenone by Streptomyces coelicolor cytochrome P450 154A1 without oxidation/reduction.

Authors:  Qian Cheng; David C Lamb; Steven L Kelly; Li Lei; F Peter Guengerich
Journal:  J Am Chem Soc       Date:  2010-11-03       Impact factor: 15.419

Review 4.  Orphans in the human cytochrome P450 superfamily: approaches to discovering functions and relevance in pharmacology.

Authors:  F Peter Guengerich; Qian Cheng
Journal:  Pharmacol Rev       Date:  2011-07-07       Impact factor: 25.468

5.  Role of the alanine at position 363 of cytochrome P450 2B2 in influencing the NADPH- and hydroperoxide-supported activities.

Authors:  I H Hanna; J F Teiber; K L Kokones; P F Hollenberg
Journal:  Arch Biochem Biophys       Date:  1998-02-15       Impact factor: 4.013

6.  Signature-discovery approach for sample matching of a nerve-agent precursor using liquid chromatography-mass spectrometry, XCMS, and chemometrics.

Authors:  Carlos G Fraga; Brian H Clowers; Ronald J Moore; Erika M Zink
Journal:  Anal Chem       Date:  2010-05-15       Impact factor: 6.986

Review 7.  Approaches to deorphanization of human and microbial cytochrome P450 enzymes.

Authors:  F Peter Guengerich; Zhongmei Tang; Qian Cheng; S Giovanna Salamanca-Pinzón
Journal:  Biochim Biophys Acta       Date:  2010-05-20
  7 in total
  4 in total

Review 1.  PubChem applications in drug discovery: a bibliometric analysis.

Authors:  Tiejun Cheng; Yongmei Pan; Ming Hao; Yanli Wang; Stephen H Bryant
Journal:  Drug Discov Today       Date:  2014-08-27       Impact factor: 7.851

2.  Molecular characterization of two A-type P450s, WsCYP98A and WsCYP76A from Withania somnifera (L.) Dunal: expression analysis and withanolide accumulation in response to exogenous elicitations.

Authors:  Satiander Rana; Wajid Waheed Bhat; Niha Dhar; Shahzad A Pandith; Sumeer Razdan; Ram Vishwakarma; Surrinder K Lattoo
Journal:  BMC Biotechnol       Date:  2014-11-23       Impact factor: 2.563

3.  Orphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish.

Authors:  Nadja R Brun; Matthew C Salanga; Francisco X Mora-Zamorano; David C Lamb; Jared V Goldstone; John J Stegeman
Journal:  Sci Rep       Date:  2021-12-13       Impact factor: 4.996

4.  Structural Characterization of an S-enantioselective Imine Reductase from Mycobacterium Smegmatis.

Authors:  Timo Meyer; Nadine Zumbrägel; Christina Geerds; Harald Gröger; Hartmut H Niemann
Journal:  Biomolecules       Date:  2020-07-31
  4 in total

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