Literature DB >> 25168772

PubChem applications in drug discovery: a bibliometric analysis.

Tiejun Cheng1, Yongmei Pan1, Ming Hao1, Yanli Wang2, Stephen H Bryant3.   

Abstract

A bibliometric analysis of PubChem applications is presented by reviewing 1132 research articles. The massive volume of chemical structure and bioactivity data in PubChem and its online services have been used globally in various fields including chemical biology, medicinal chemistry and informatics research. PubChem supports drug discovery in many aspects such as lead identification and optimization, compound-target profiling, polypharmacology studies and unknown chemical identity elucidation. PubChem has also become a valuable resource for developing secondary databases, informatics tools and web services. The growing PubChem resource with its public availability offers support and great opportunities for the interrogation of pharmacological mechanisms and the genetic basis of diseases, which are vital for drug innovation and repurposing. Published by Elsevier Ltd.

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Year:  2014        PMID： 25168772      PMCID： PMC4252728          DOI： 10.1016/j.drudis.2014.08.008

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  58 in total

1.  Data mining a small molecule drug screening representative subset from NIH PubChem.

Authors:  Xiang-Qun Xie; Jian-Zhong Chen
Journal:  J Chem Inf Model       Date:  2008-02-27       Impact factor: 4.956

2.  PubChem as a source of polypharmacology.

Authors:  Bin Chen; David Wild; Rajarshi Guha
Journal:  J Chem Inf Model       Date:  2009-09       Impact factor: 4.956

3.  Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening.

Authors:  Debra A O'Leary; Orzala Sharif; Paul Anderson; Buu Tu; Genevieve Welch; Yingyao Zhou; Jeremy S Caldwell; Ingo H Engels; Achim Brinker
Journal:  PLoS One       Date:  2009-12-17       Impact factor: 3.240

4.  Visualisation of the chemical space of fragments, lead-like and drug-like molecules in PubChem.

Authors:  Ruud van Deursen; Lorenz C Blum; Jean-Louis Reymond
Journal:  J Comput Aided Mol Des       Date:  2011-05-27       Impact factor: 3.686

5.  Fragment-based design of small molecule X-linked inhibitor of apoptosis protein inhibitors.

Authors:  Jui-Wen Huang; Ziming Zhang; Bainan Wu; Jason F Cellitti; Xiyun Zhang; Russell Dahl; Chung-Wai Shiau; Kate Welsh; Aras Emdadi; John L Stebbins; John C Reed; Maurizio Pellecchia
Journal:  J Med Chem       Date:  2008-11-27       Impact factor: 7.446

6.  High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.

Authors:  Samuel A Hasson; Lesley A Kane; Koji Yamano; Chiu-Hui Huang; Danielle A Sliter; Eugen Buehler; Chunxin Wang; Sabrina M Heman-Ackah; Tara Hessa; Rajarshi Guha; Scott E Martin; Richard J Youle
Journal:  Nature       Date:  2013-11-24       Impact factor: 49.962

7.  Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods.

Authors:  Hanyong Chen; Ke Yao; Janos Nadas; Ann M Bode; Margarita Malakhova; Naomi Oi; Haitao Li; Ronald A Lubet; Zigang Dong
Journal:  PLoS One       Date:  2012-05-31       Impact factor: 3.240

8.  LYP inhibits T-cell activation when dissociated from CSK.

Authors:  Torkel Vang; Wallace H Liu; Laurence Delacroix; Shuangding Wu; Stefan Vasile; Russell Dahl; Li Yang; Lucia Musumeci; Dana Francis; Johannes Landskron; Kjetil Tasken; Michel L Tremblay; Benedicte A Lie; Rebecca Page; Tomas Mustelin; Souad Rahmouni; Robert C Rickert; Lutz Tautz
Journal:  Nat Chem Biol       Date:  2012-03-18       Impact factor: 15.040

9.  A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes.

Authors:  Zheng Yin; Amine Sadok; Heba Sailem; Afshan McCarthy; Xiaofeng Xia; Fuhai Li; Mar Arias Garcia; Louise Evans; Alexis R Barr; Norbert Perrimon; Christopher J Marshall; Stephen T C Wong; Chris Bakal
Journal:  Nat Cell Biol       Date:  2013-06-09       Impact factor: 28.824

10.  An overview of the PubChem BioAssay resource.

Authors:  Yanli Wang; Evan Bolton; Svetlana Dracheva; Karen Karapetyan; Benjamin A Shoemaker; Tugba O Suzek; Jiyao Wang; Jewen Xiao; Jian Zhang; Stephen H Bryant
Journal:  Nucleic Acids Res       Date:  2009-11-19       Impact factor: 16.971
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  14 in total

1.  Dyslexia: A Bibliometric and Visualization Analysis.

Authors:  Yanqi Wu; Yanxia Cheng; Xianlin Yang; Wenyan Yu; Yuehua Wan
Journal:  Front Public Health       Date:  2022-06-23

2.  DCDB 2.0: a major update of the drug combination database.

Authors:  Yanbin Liu; Qiang Wei; Guisheng Yu; Wanxia Gai; Yongquan Li; Xin Chen
Journal:  Database (Oxford)       Date:  2014-12-23       Impact factor: 3.451

3.  Cheminformatics analysis of the AR agonist and antagonist datasets in PubChem.

Authors:  Ming Hao; Stephen H Bryant; Yanli Wang
Journal:  J Cheminform       Date:  2016-07-08       Impact factor: 5.514

4.  PubChem BioAssay: 2017 update.

Authors:  Yanli Wang; Stephen H Bryant; Tiejun Cheng; Jiyao Wang; Asta Gindulyte; Benjamin A Shoemaker; Paul A Thiessen; Siqian He; Jian Zhang
Journal:  Nucleic Acids Res       Date:  2016-11-29       Impact factor: 16.971

5.  Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2008-2014.

Authors:  Thomas Luechtefeld; Alexandra Maertens; Daniel P Russo; Costanza Rovida; Hao Zhu; Thomas Hartung
Journal:  ALTEX       Date:  2016-02-11       Impact factor: 6.043

6.  Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data.

Authors:  Thomas Luechtefeld; Alexandra Maertens; Daniel P Russo; Costanza Rovida; Hao Zhu; Thomas Hartung
Journal:  ALTEX       Date:  2016-02-11       Impact factor: 6.043

7.  How Reliable Are Ligand-Centric Methods for Target Fishing?

Authors:  Antonio Peón; Cuong C Dang; Pedro J Ballester
Journal:  Front Chem       Date:  2016-04-14       Impact factor: 5.221

8.  Treating Diabetes Mellitus: Pharmacophore Based Designing of Potential Drugs from Gymnema sylvestre against Insulin Receptor Protein.

Authors:  Mohammad Uzzal Hossain; Md Arif Khan; S M Rakib-Uz-Zaman; Mohammad Tuhin Ali; Md Saidul Islam; Chaman Ara Keya; Md Salimullah
Journal:  Biomed Res Int       Date:  2016-02-28       Impact factor: 3.411

9.  Using Social Media Data to Identify Potential Candidates for Drug Repurposing: A Feasibility Study.

Authors:  Majid Rastegar-Mojarad; Hongfang Liu; Priya Nambisan
Journal:  JMIR Res Protoc       Date:  2016-06-16

10.  PubChem BioAssay: A Decade's Development toward Open High-Throughput Screening Data Sharing.

Authors:  Yanli Wang; Tiejun Cheng; Stephen H Bryant
Journal:  SLAS Discov       Date:  2017-01-13       Impact factor: 3.341
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