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Literature DB >> 23466623

Osteosarcoma tumor thrombus: a case report with a review of the literature.

Pournima Navalkele¹, Sarah M Jones, Jason K Jones, Jorge D Salazar, Patrick C Toy, Rathi V Iyer, Betty Herrington.

Abstract

Tumor thrombus arising from osteosarcoma is rare. We report the case of a 20-year-old man with proximal humerus osteosarcoma, accompanied by an extensive intravascular tumor thrombus extending into the heart. Our review of the literature found 14 previous reports on osteosarcoma with tumor thrombus. The combination of positron emission tomography and computed tomography is very useful in differentiating tumor thrombus from vascular thrombus, thereby avoiding unnecessary anticoagulation therapy. This same imaging combination can also be used to evaluate the response to treatment. Surgical resection of the tumor thrombus is highly recommended. The effect of tumor thrombus on survival is still unknown.

Entities: Disease Species

Keywords: Bone neoplasms/complications; chondrosarcoma; humerus/pathology; neoplasm invasiveness; osteosarcoma/diagnosis/pathology/therapy; positron-emission tomography; thrombosis; tomography, x-ray computed; vascular neoplasms

Mesh：

Year: 2013 PMID： 23466623 PMCID： PMC3568289

Source DB: PubMed Journal: Tex Heart Inst J ISSN： 0730-2347

18 in total

1. Pulmonary infarction resulting from metastatic osteogenic sarcoma with pulmonary venous tumor thrombus.

Authors: E Nelson; J S Klein
Journal: AJR Am J Roentgenol Date: 2000-02 Impact factor: 3.959

2. Successful resection of osteosarcoma pulmonary metastasis extending into left side of heart under cardiopulmonary bypass: a case report.

Authors: Ying Chai; Gang Shen
Journal: Chin Med J (Engl) Date: 2002-11 Impact factor: 2.628

3. Osteosarcoma metastatic to the kidney with invasion of the inferior vena cava.

Authors: C M King; R H Reznek; A J Norton; J E Kingston
Journal: Br J Radiol Date: 1992-09 Impact factor: 3.039

4. Arteriographic demonstration of intravenous tumor extension.

Authors: F P Gregg; H M Goldstein; S Wallace; J H Casey
Journal: Am J Roentgenol Radium Ther Nucl Med Date: 1975-01

5. Deep venous occlusion as the initial presentation of osteogenic sarcoma of the sacrum. A case report.

Authors: A M Levine; P Chretien
Journal: J Bone Joint Surg Am Date: 1979-07 Impact factor: 5.284

6. Vascular invasion in high grade sarcoma of the extremity is associated with short overall survival.

Authors: O Merimsky; J Isakov; Y Kollender; A Nirkin; M Inbar; I Meller
Journal: Oncol Rep Date: 1998 Jul-Aug Impact factor: 3.906

7. Inferior vena cava thrombus removal using hypothermic circulatory arrest in two patients with osteosarcoma.

Authors: Nicholas D Garcia; Mark D Morasch; Albert D Sam; Robert L Satcher; Matthew G Blum; David A Fullerton
Journal: Ann Vasc Surg Date: 2003-11 Impact factor: 1.466

8. Right atrial and ventricular thrombus infiltrated with osteoblastic osteosarcoma.

Authors: Atman P Shah; Simrit Parmar; Ruth O'Regan
Journal: J Cardiovasc Pharmacol Ther Date: 2003-12 Impact factor: 2.457

9. Inferior vena cava--right atrial tumor thrombus in malignant pelvic bone tumors in children.

Authors: C T Giuliano; W M Kauffman; J O Haller; B D Fletcher; S P Rao
Journal: Pediatr Radiol Date: 1992

Review 10. Pediatric osteogenic sarcoma.

Authors: Han Jo Kim; Peter N Chalmers; Carol D Morris
Journal: Curr Opin Pediatr Date: 2010-02 Impact factor: 2.856

7 in total

7. Radiological characteristics and predisposing factors of venous tumor thrombus in pelvic osteosarcoma: A mono-institutional retrospective study of 115 cases.

Authors: Haijie Liang; Wei Guo; Rongli Yang; Xiaodong Tang; Taiqiang Yan; Tao Ji; Yi Yang; Dasen Li; Lu Xie; Jie Xu
Journal: Cancer Med Date: 2018-08-23 Impact factor: 4.452

7 in total

Osteosarcoma tumor thrombus: a case report with a review of the literature.

1. Pulmonary infarction resulting from metastatic osteogenic sarcoma with pulmonary venous tumor thrombus.

2. Successful resection of osteosarcoma pulmonary metastasis extending into left side of heart under cardiopulmonary bypass: a case report.

3. Osteosarcoma metastatic to the kidney with invasion of the inferior vena cava.

4. Arteriographic demonstration of intravenous tumor extension.

5. Deep venous occlusion as the initial presentation of osteogenic sarcoma of the sacrum. A case report.

6. Vascular invasion in high grade sarcoma of the extremity is associated with short overall survival.

7. Inferior vena cava thrombus removal using hypothermic circulatory arrest in two patients with osteosarcoma.

8. Right atrial and ventricular thrombus infiltrated with osteoblastic osteosarcoma.

9. Inferior vena cava--right atrial tumor thrombus in malignant pelvic bone tumors in children.

Review 10. Pediatric osteogenic sarcoma.

1. Prognostic Value of Vascular Invasion in Pediatric Osteosarcomas.

2. Cardiovascular involvement by osteosarcoma: an analysis of 20 patients.

3. [Uncommon tumor-associated deep vein thrombosis].

4. Venous tumor thrombus from a pelvic osteosarcoma.

Review 5. Pulmonary tumor embolism secondary to soft tissue and bone sarcomas: a case report and literature review.

6. Successful Complete Response of Tumor Thrombus after Combined with Chemotherapy and Irradiation for Ewing Sarcoma.

7. Radiological characteristics and predisposing factors of venous tumor thrombus in pelvic osteosarcoma: A mono-institutional retrospective study of 115 cases.