PURPOSE OF REVIEW: Osteogenic sarcoma, also known as osteosarcoma, is a primary malignancy of the bone in which spindle cells produce osteoid. Although rare in the general population, these tumors are the most common primary malignancies of bone and the fifth most common primary malignancy of adolescence. This paper aims to provide a general overview on the presentation, radiographic evaluation, and treatment of osteosarcoma as it presents in the pediatric patient population. Particular focus is placed on the importance of a comprehensive team of physicians, including the pediatric oncologist and orthopedic surgeon, to ensure prompt diagnosis and treatment. RECENT FINDINGS: Survival for osteosarcoma tumor has changed significantly due to advanced chemotherapeutic regimens; current data place 5-year survival rates at 60% or greater. In addition, limb-sparing surgery has largely supplanted amputation, though the effect of this change on functional outcomes is controversial. Recent studies have shown greatly improved long-term survival data using current therapeutic regimens at tertiary referral centers. SUMMARY: Advancement in chemotherapeutic regimens has allowed improved survival and limb-sparing surgery in the treatment of osteosarcoma.
PURPOSE OF REVIEW: Osteogenic sarcoma, also known as osteosarcoma, is a primary malignancy of the bone in which spindle cells produce osteoid. Although rare in the general population, these tumors are the most common primary malignancies of bone and the fifth most common primary malignancy of adolescence. This paper aims to provide a general overview on the presentation, radiographic evaluation, and treatment of osteosarcoma as it presents in the pediatric patient population. Particular focus is placed on the importance of a comprehensive team of physicians, including the pediatric oncologist and orthopedic surgeon, to ensure prompt diagnosis and treatment. RECENT FINDINGS: Survival for osteosarcoma tumor has changed significantly due to advanced chemotherapeutic regimens; current data place 5-year survival rates at 60% or greater. In addition, limb-sparing surgery has largely supplanted amputation, though the effect of this change on functional outcomes is controversial. Recent studies have shown greatly improved long-term survival data using current therapeutic regimens at tertiary referral centers. SUMMARY: Advancement in chemotherapeutic regimens has allowed improved survival and limb-sparing surgery in the treatment of osteosarcoma.
Authors: Matthew T Houdek; Eric R Wagner; Anthony A Stans; Alexander Y Shin; Allen T Bishop; Franklin H Sim; Steven L Moran Journal: Clin Orthop Relat Res Date: 2016-03 Impact factor: 4.176
Authors: Pournima Navalkele; Sarah M Jones; Jason K Jones; Jorge D Salazar; Patrick C Toy; Rathi V Iyer; Betty Herrington Journal: Tex Heart Inst J Date: 2013
Authors: Rebecca Sowers; Bethanne D Wenzel; Condon Richardson; Paul A Meyers; John H Healey; Adam S Levy; Richard Gorlick Journal: Sarcoma Date: 2010-12-22
Authors: Yun-Shan Guo; Rui Zhao; Jie Ma; Wei Cui; Zhen Sun; Bo Gao; Shu He; Yue-Hu Han; Jing Fan; Liu Yang; Juan Tang; Zhuo-Jing Luo Journal: PLoS One Date: 2014-03-04 Impact factor: 3.240