Literature DB >> 23463940

Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography.

Jinhe Pan1, Joseph Lau, Felix Mesak, Navjit Hundal, Maral Pourghiasian, Zhibo Liu, François Bénard, Shoukat Dedhar, Claudiu T Supuran, Kuo-Shyan Lin.   

Abstract

Two carbonic anhydrase IX (CA IX) inhibitors were radiolabeled with (18)F, and evaluated for imaging CA IX expression. Despite good affinity for CA IX and excellent plasma stability, uptake of both tracers in CA IX-expressing HT-29 tumor xenografts in mice was low. (18)F-FEC accumulated predominately in the liver and nasal cavity, whereas a significant amount of (18)F-U-104 was retained in blood. Due to minimal uptake in HT-29 tumors compared to other organs/tissues, these two tracers are not suitable for use for CA IX-targeted imaging.

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Year:  2013        PMID： 23463940     DOI： 10.3109/14756366.2013.773994

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  13 in total

1.  pH-Sensitive Multiligand Gold Nanoplatform Targeting Carbonic Anhydrase IX Enhances the Delivery of Doxorubicin to Hypoxic Tumor Spheroids and Overcomes the Hypoxia-Induced Chemoresistance.

Authors:  Ahmed M Shabana; Utpal K Mondal; Md Raqibul Alam; Taylor Spoon; Codee Alicia Ross; Muniswamy Madesh; Claudiu T Supuran; Marc A Ilies
Journal:  ACS Appl Mater Interfaces       Date:  2018-05-15       Impact factor: 9.229

Review 2.  New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents.

Authors:  Kuo-Ting Chen; Yann Seimbille
Journal:  Int J Mol Sci       Date:  2022-05-30       Impact factor: 6.208

3.  Evaluation of Nonpeptidic Ligand Conjugates for SPECT Imaging of Hypoxic and Carbonic Anhydrase IX-Expressing Cancers.

Authors:  Peng-Cheng Lv; Karson S Putt; Philip S Low
Journal:  Bioconjug Chem       Date:  2016-07-07       Impact factor: 4.774

Review 4.  Carbonic Anhydrase Inhibition and the Management of Hypoxic Tumors.

Authors:  Claudiu T Supuran
Journal:  Metabolites       Date:  2017-09-16

5.  [64Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma.

Authors:  Il Minn; Soo Min Koo; Hye Soo Lee; Mary Brummet; Steven P Rowe; Michael A Gorin; Polina Sysa-Shah; William D Lewis; Hye-Hyun Ahn; Yuchuan Wang; Sangeeta Ray Banerjee; Ronnie C Mease; Sridhar Nimmagadda; Mohamad E Allaf; Martin G Pomper; Xing Yang
Journal:  Oncotarget       Date:  2016-08-30

6.  Design, synthesis and evaluation of 18F-labeled cationic carbonic anhydrase IX inhibitors for PET imaging.

Authors:  Zhengxing Zhang; Joseph Lau; Chengcheng Zhang; Nadine Colpo; Alessio Nocentini; Claudiu T Supuran; François Bénard; Kuo-Shyan Lin
Journal:  J Enzyme Inhib Med Chem       Date:  2017-12       Impact factor: 5.051

7.  Imaging of carbonic anhydrase IX with an 111In-labeled dual-motif inhibitor.

Authors:  Xing Yang; Il Minn; Steven P Rowe; Sangeeta Ray Banerjee; Michael A Gorin; Mary Brummet; Hye Soo Lee; Soo Min Koo; Polina Sysa-Shah; Ronnie C Mease; Sridhar Nimmagadda; Mohamad E Allaf; Martin G Pomper
Journal:  Oncotarget       Date:  2015-10-20

Review 8.  Past, Present, and Future: Development of Theranostic Agents Targeting Carbonic Anhydrase IX.

Authors:  Joseph Lau; Kuo-Shyan Lin; François Bénard
Journal:  Theranostics       Date:  2017-09-26       Impact factor: 11.556

9.  Cancer radiotheranostics targeting carbonic anhydrase-IX with 111In- and 90Y-labeled ureidosulfonamide scaffold for SPECT imaging and radionuclide-based therapy.

Authors:  Shimpei Iikuni; Masahiro Ono; Hiroyuki Watanabe; Yoichi Shimizu; Kohei Sano; Hideo Saji
Journal:  Theranostics       Date:  2018-04-30       Impact factor: 11.556

10.  Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors.

Authors:  Emanuela Berrino; Silvia Bua; Mattia Mori; Maurizio Botta; Vallabhaneni S Murthy; Vijayaparthasarathi Vijayakumar; Yasinalli Tamboli; Gianluca Bartolucci; Alessandro Mugelli; Elisabetta Cerbai; Claudiu T Supuran; Fabrizio Carta
Journal:  Molecules       Date:  2017-06-24       Impact factor: 4.411
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