Literature DB >> 23460402

Direct synthesis of fluorinated heteroarylether bioisosteres.

Qianghui Zhou1, Alessandro Ruffoni, Ryan Gianatassio, Yuta Fujiwara, Eran Sella, Doron Shabat, Phil S Baran.   

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Year:  2013        PMID： 23460402      PMCID： PMC3643141          DOI： 10.1002/anie.201300763

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  11 in total

1.  Aiming for the ideal synthesis.

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2.  Synopsis of some recent tactical application of bioisosteres in drug design.

Authors:  Nicholas A Meanwell
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3.  Difluoromethyl 2-pyridyl sulfone: a new gem-difluoroolefination reagent for aldehydes and ketones.

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Journal:  Org Lett       Date:  2010-04-02       Impact factor: 6.005

4.  From difluoromethyl 2-pyridyl sulfone to difluorinated sulfonates: a protocol for nucleophilic difluoro(sulfonato)methylation.

Authors:  G K Surya Prakash; Chuanfa Ni; Fang Wang; Jinbo Hu; George A Olah
Journal:  Angew Chem Int Ed Engl       Date:  2011-02-18       Impact factor: 15.336

5.  Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.

Authors:  Jose M Coteron; María Marco; Jorge Esquivias; Xiaoyi Deng; Karen L White; John White; Maria Koltun; Farah El Mazouni; Sreekanth Kokkonda; Kasiram Katneni; Ravi Bhamidipati; David M Shackleford; Iñigo Angulo-Barturen; Santiago B Ferrer; María Belén Jiménez-Díaz; Francisco-Javier Gamo; Elizabeth J Goldsmith; William N Charman; Ian Bathurst; David Floyd; David Matthews; Jeremy N Burrows; Pradipsinh K Rathod; Susan A Charman; Margaret A Phillips
Journal:  J Med Chem       Date:  2011-07-14       Impact factor: 7.446

6.  A new reagent for direct difluoromethylation.

Authors:  Yuta Fujiwara; Janice A Dixon; Rodrigo A Rodriguez; Ryan D Baxter; Darryl D Dixon; Michael R Collins; Donna G Blackmond; Phil S Baran
Journal:  J Am Chem Soc       Date:  2012-01-13       Impact factor: 15.419

7.  Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B.

Authors:  Marc O Anderson; Jicheng Zhang; Yan Liu; Chenjuan Yao; Puay-Wah Phuan; A S Verkman
Journal:  J Med Chem       Date:  2012-06-19       Impact factor: 7.446

8.  Practical method for the Cu-mediated trifluoromethylation of arylboronic acids with CF3 radicals derived from NaSO2CF3 and tert-butyl hydroperoxide (TBHP).

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Journal:  Org Lett       Date:  2012-09-17       Impact factor: 6.005

9.  Copper- and iron-catalyzed decarboxylative tri- and difluoromethylation of α,β-unsaturated carboxylic acids with CF3SO2Na and (CF2HSO2)2Zn via a radical process.

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Journal:  Org Lett       Date:  2013-01-10       Impact factor: 6.005

10.  Practical and innate carbon-hydrogen functionalization of heterocycles.

Authors:  Yuta Fujiwara; Janice A Dixon; Fionn O'Hara; Erik Daa Funder; Darryl D Dixon; Rodrigo A Rodriguez; Ryan D Baxter; Bart Herlé; Neal Sach; Michael R Collins; Yoshihiro Ishihara; Phil S Baran
Journal:  Nature       Date:  2012-11-28       Impact factor: 49.962
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  22 in total

1.  Regio- and Enantioselective Bromocyclization of Difluoroalkenes as a Strategy to Access Tetrasubstituted Difluoromethylene-Containing Stereocenters.

Authors:  Edward Miller; Suhong Kim; Katarina Gibson; Jeffrey S Derrick; F Dean Toste
Journal:  J Am Chem Soc       Date:  2020-04-30       Impact factor: 15.419

2.  Generating Stereodiversity: Diastereoselective Fluorination and Highly Diastereoselective Epimerization of α-Amino Acid Building Blocks.

Authors:  Wei Wei; Rama Kanwar Khangarot; Lothar Stahl; Cristina Veresmortean; Padmanava Pradhan; Lijia Yang; Barbara Zajc
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3.  Selective C-F Functionalization of Unactivated Trifluoromethylarenes.

Authors:  David B Vogt; Ciaran P Seath; Hengbin Wang; Nathan T Jui
Journal:  J Am Chem Soc       Date:  2019-08-09       Impact factor: 15.419

4.  Late-Stage C-H Alkylation of Heterocycles and 1,4-Quinones via Oxidative Homolysis of 1,4-Dihydropyridines.

Authors:  Álvaro Gutiérrez-Bonet; Camille Remeur; Jennifer K Matsui; Gary A Molander
Journal:  J Am Chem Soc       Date:  2017-08-23       Impact factor: 15.419

5.  Bioconjugation by native chemical tagging of C-H bonds.

Authors:  Qianghui Zhou; Jinghan Gui; Chung-Mao Pan; Earl Albone; Xin Cheng; Edward M Suh; Luigi Grasso; Yoshihiro Ishihara; Phil S Baran
Journal:  J Am Chem Soc       Date:  2013-08-22       Impact factor: 15.419

6.  Radical-based regioselective C-H functionalization of electron-deficient heteroarenes: scope, tunability, and predictability.

Authors:  Fionn O'Hara; Donna G Blackmond; Phil S Baran
Journal:  J Am Chem Soc       Date:  2013-07-30       Impact factor: 15.419

7.  Palladium-catalyzed intramolecular C-H difluoroalkylation: synthesis of substituted 3,3-difluoro-2-oxindoles.

Authors:  Shi-Liang Shi; Stephen L Buchwald
Journal:  Angew Chem Int Ed Engl       Date:  2014-12-04       Impact factor: 15.336

Review 8.  Chemo- and site-selective derivatizations of natural products enabling biological studies.

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Journal:  Nat Prod Rep       Date:  2014-03       Impact factor: 13.423

9.  Simple sulfinate synthesis enables C-H trifluoromethylcyclopropanation.

Authors:  Ryan Gianatassio; Shuhei Kawamura; Cecil L Eprile; Klement Foo; Jason Ge; Aaron C Burns; Michael R Collins; Phil S Baran
Journal:  Angew Chem Int Ed Engl       Date:  2014-08-03       Impact factor: 15.336

10.  Visible light-promoted metal-free C-H activation: diarylketone-catalyzed selective benzylic mono- and difluorination.

Authors:  Ji-Bao Xia; Chen Zhu; Chuo Chen
Journal:  J Am Chem Soc       Date:  2013-11-12       Impact factor: 15.419
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