Literature DB >> 20210302

Difluoromethyl 2-pyridyl sulfone: a new gem-difluoroolefination reagent for aldehydes and ketones.

Yanchuan Zhao1, Weizhou Huang, Lingui Zhu, Jinbo Hu.   

Abstract

Difluoromethyl 2-pyridyl sulfone, a previously unknown compound, was found to act as a novel and efficient gem-difluoroolefination reagent for both aldehydes and ketones. It was found that the fluorinated sulfinate intermediate in the reaction is relatively stable, which can be observed by (19)F NMR and trapped with CH(3)I.

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Year:  2010        PMID： 20210302     DOI： 10.1021/ol100090r

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  18 in total

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7.  Palladium-Catalyzed Defluorinative Coupling of 1-Aryl-2,2-Difluoroalkenes and Boronic Acids: Stereoselective Synthesis of Monofluorostilbenes.

Authors:  Richard T Thornbury; F Dean Toste
Journal:  Angew Chem Int Ed Engl       Date:  2016-08-11       Impact factor: 15.336

8.  Synthesis of Fluoroolefins via Julia-Kocienski Olefination.

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9.  Synthesis of regiospecifically fluorinated conjugated dienamides.

Authors:  Mohammad Chowdhury; Samir K Mandal; Shaibal Banerjee; Barbara Zajc
Journal:  Molecules       Date:  2014-04-10       Impact factor: 4.411

10.  Consecutive cross-coupling reactions of 2,2-difluoro-1-iodoethenyl tosylate with boronic acids: efficient synthesis of 1,1-diaryl-2,2-difluoroethenes.

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Journal:  Beilstein J Org Chem       Date:  2013-11-14       Impact factor: 2.883
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