Literature DB >> 26835096

Biology of the Sinus Node and its Disease.

Moinuddin Choudhury1, Mark R Boyett1, Gwilym M Morris1.   

Abstract

The sinoatrial node (SAN) is the normal pacemaker of the heart and SAN dysfunction (SND) is common, but until recently the pathophysiology was incompletely understood. It was usually attributed to idiopathic age-related fibrosis and cell atrophy or ischaemia. It is now evident that changes in the electrophysiology of the SAN, known as electrical remodelling, is an important process that has been demonstrated in SND associated with heart failure, ageing, diabetes, atrial fibrillation and endurance exercise. Furthermore, familial SND has been identified and mutations have been characterised in key pacemaker genes of the SAN. This review summarises the current evidence regarding SAN function and the pathophysiology of SND.

Entities:  

Keywords:  Sinoatrial node; atrial fibrillation; biological pacemaker; calcium clock; membrane clock; pacemaking; sick sinus syndrome; sinus node disease; sinus node dysfunction; tachy-brady

Year:  2015        PMID： 26835096      PMCID： PMC4711507          DOI： 10.15420/aer.2015.4.1.28

Source DB:  PubMed          Journal:  Arrhythm Electrophysiol Rev        ISSN： 2050-3369


  84 in total

1.  T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.

Authors:  Martijn L Bakker; Gerard J J Boink; Bas J Boukens; Arie O Verkerk; Malou van den Boogaard; A Denise den Haan; Willem M H Hoogaars; Henk P Buermans; Jacques M T de Bakker; Jurgen Seppen; Hanno L Tan; Antoon F M Moorman; Peter A C 't Hoen; Vincent M Christoffels
Journal:  Cardiovasc Res       Date:  2012-03-14       Impact factor: 10.787

2.  Role of sinus node artery disease in sick sinus syndrome in inferior wall acute myocardial infarction.

Authors:  P Alboni; G F Baggioni; S Scarfò; R Cappato; G F Percoco; N Paparella; G E Antonioli
Journal:  Am J Cardiol       Date:  1991-06-01       Impact factor: 2.778

3.  Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patients.

Authors:  A V Postma; I Denjoy; J Kamblock; M Alders; J-M Lupoglazoff; G Vaksmann; L Dubosq-Bidot; P Sebillon; M M A M Mannens; P Guicheney; A A M Wilde
Journal:  J Med Genet       Date:  2005-11       Impact factor: 6.318

4.  Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit.

Authors:  James O Tellez; Halina Dobrzynski; Ian D Greener; Gillian M Graham; Emma Laing; Haruo Honjo; Simon J Hubbard; Mark R Boyett; Rudi Billeter
Journal:  Circ Res       Date:  2006-11-02       Impact factor: 17.367

5.  Pathological studies in sinoatrial disorder (sick sinus syndrome).

Authors:  R Evans; D B Shaw
Journal:  Br Heart J       Date:  1977-07

6.  Sinus pacemaker function after cardioversion of chronic atrial fibrillation: is sinus node remodeling related with recurrence?

Authors:  E G Manios; E M Kanoupakis; H E Mavrakis; E M Kallergis; D N Dermitzaki; P E Vardas
Journal:  J Cardiovasc Electrophysiol       Date:  2001-07

7.  Absence of calsequestrin 2 causes severe forms of catecholaminergic polymorphic ventricular tachycardia.

Authors:  Alex V Postma; Isabelle Denjoy; Theo M Hoorntje; Jean-Marc Lupoglazoff; Antoine Da Costa; Pascale Sebillon; Marcel M A M Mannens; Arthur A M Wilde; Pascale Guicheney
Journal:  Circ Res       Date:  2002-10-18       Impact factor: 17.367

8.  Biological pacemaker implanted in canine left bundle branch provides ventricular escape rhythms that have physiologically acceptable rates.

Authors:  Alexei N Plotnikov; Eugene A Sosunov; Jihong Qu; Iryna N Shlapakova; Evgeny P Anyukhovsky; Lili Liu; Michiel J Janse; Peter R Brink; Ira S Cohen; Richard B Robinson; Peter Danilo; Michael R Rosen
Journal:  Circulation       Date:  2004-01-20       Impact factor: 29.690

9.  Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease.

Authors:  Solena Le Scouarnec; Naina Bhasin; Claude Vieyres; Thomas J Hund; Shane R Cunha; Olha Koval; Celine Marionneau; Biyi Chen; Yuejin Wu; Sophie Demolombe; Long-Sheng Song; Hervé Le Marec; Vincent Probst; Jean-Jacques Schott; Mark E Anderson; Peter J Mohler
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-01       Impact factor: 11.205

10.  The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart.

Authors:  Willem M H Hoogaars; Alessandra Tessari; Antoon F M Moorman; Piet A J de Boer; Jaco Hagoort; Alexandre T Soufan; Marina Campione; Vincent M Christoffels
Journal:  Cardiovasc Res       Date:  2004-06-01       Impact factor: 10.787
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  24 in total

1.  Genome-wide association study of heart rate and its variability in Hispanic/Latino cohorts.

Authors:  Kathleen F Kerr; Christy L Avery; Henry J Lin; Laura M Raffield; Qian S Zhang; Brian L Browning; Sharon R Browning; Matthew P Conomos; Stephanie M Gogarten; Cathy C Laurie; Tamar Sofer; Timothy A Thornton; Chancellor Hohensee; Rebecca D Jackson; Charles Kooperberg; Yun Li; Raúl Méndez-Giráldez; Marco V Perez; Ulrike Peters; Alexander P Reiner; Zhu-Ming Zhang; Jie Yao; Nona Sotoodehnia; Kent D Taylor; Xiuqing Guo; Leslie A Lange; Elsayed Z Soliman; James G Wilson; Jerome I Rotter; Susan R Heckbert; Deepti Jain; Eric A Whitsel
Journal:  Heart Rhythm       Date:  2017-06-10       Impact factor: 6.343

2.  Transcriptomic Profiling of the Developing Cardiac Conduction System at Single-Cell Resolution.

Authors:  William R Goodyer; Benjamin M Beyersdorf; David T Paik; Lei Tian; Guang Li; Jan W Buikema; Orlando Chirikian; Shannon Choi; Sneha Venkatraman; Eliza L Adams; Marc Tessier-Lavigne; Joseph C Wu; Sean M Wu
Journal:  Circ Res       Date:  2019-07-09       Impact factor: 17.367

Review 3.  Development of the cardiac pacemaker.

Authors:  Xingqun Liang; Sylvia M Evans; Yunfu Sun
Journal:  Cell Mol Life Sci       Date:  2016-10-21       Impact factor: 9.261

Review 4.  Cancer Chemotherapy-Induced Sinus Bradycardia: A Narrative Review of a Forgotten Adverse Effect of Cardiotoxicity.

Authors:  Juan Tamargo; Ricardo Caballero; Eva Delpón
Journal:  Drug Saf       Date:  2022-01-13       Impact factor: 5.606

5.  Frequency-Dependent Properties of the Hyperpolarization-Activated Cation Current, If, in Adult Mouse Heart Primary Pacemaker Myocytes.

Authors:  Wei Hu; Robert B Clark; Wayne R Giles; Colleen Kondo; Henggui Zhang
Journal:  Int J Mol Sci       Date:  2022-04-13       Impact factor: 6.208

Review 6.  On the Evolution of the Cardiac Pacemaker.

Authors:  Silja Burkhard; Vincent van Eif; Laurence Garric; Vincent M Christoffels; Jeroen Bakkers
Journal:  J Cardiovasc Dev Dis       Date:  2017-04-27

7.  Clonazepam-associated Bradycardia in a Disabled Elderly Woman with Multiple Complications.

Authors:  Hidetomo Maruyoshi; Natsue Maruyoshi; Motone Hirosue; Komei Ikeda; Masaaki Shimamoto
Journal:  Intern Med       Date:  2017-08-10       Impact factor: 1.271

Review 8.  Potassium channels in the sinoatrial node and their role in heart rate control.

Authors:  Qadeer Aziz; Yiwen Li; Andrew Tinker
Journal:  Channels (Austin)       Date:  2018       Impact factor: 2.581

9.  The Organization of the Sinoatrial Node Microvasculature Varies Regionally to Match Local Myocyte Excitability.

Authors:  Nathan Grainger; Laura Guarina; Robert H Cudmore; L Fernando Santana
Journal:  Function (Oxf)       Date:  2021-06-12

10.  Tbx18 and the generation of a biological pacemaker. Are we there yet?

Authors:  Thomas Brand
Journal:  J Mol Cell Cardiol       Date:  2016-06-10       Impact factor: 5.000
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