Literature DB >> 23449792

Maribavir inhibits Epstein-Barr virus transcription through the EBV protein kinase.

Christopher B Whitehurst1, Marcia K Sanders, Mankit Law, Fu-Zhang Wang, Jie Xiong, Dirk P Dittmer, Joseph S Pagano.   

Abstract

Maribavir (MBV) inhibits Epstein-Barr virus (EBV) replication and the enzymatic activity of the viral protein kinase BGLF4. MBV also inhibits expression of multiple EBV transcripts during EBV lytic infection. Here we demonstrate, with the use of a BGLF4 knockout virus, that effects of MBV on transcription take place primarily through inhibition of BGLF4. MBV inhibits viral genome copy numbers and infectivity to levels similar to and exceeding levels produced by BGLF4 knockout virus.

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Year:  2013        PMID： 23449792      PMCID： PMC3624302          DOI： 10.1128/JVI.03505-12

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


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