Literature DB >> 21300829

Benzimidazole analogs inhibit human herpesvirus 6.

Mark N Prichard1, Samuel L Frederick, Shannon Daily, Katherine Z Borysko, Leroy B Townsend, John C Drach, Earl R Kern.   

Abstract

Several benzimidazole nucleoside analogs, including 1H-β-D-ribofuranosyl-2-bromo-5,6-dichlorobenzimidazole (BDCRB) and 1H-β-L-ribofuranosyl-2-isopropylamino-5,6-dichlorobenzimidazole (maribavir [MBV]), inhibit the replication of human cytomegalovirus. Neither analog inhibited the related betaherpesvirus human herpesvirus 6 (HHV-6). Additional analogs of these compounds were evaluated against both variants of HHV-6, and two L-analogs of BDCRB had good antiviral activity against HHV-6A, as well as more modest inhibition of HHV-6B replication.

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Year:  2011        PMID： 21300829      PMCID： PMC3088228          DOI： 10.1128/AAC.01523-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

1.  Phosphorylation of beta-D-ribosylbenzimidazoles is not required for activity against human cytomegalovirus.

Authors:  Paula M Krosky; Katherine Z Borysko; M Reza Nassiri; Rodrigo V Devivar; Roger G Ptak; Michelle G Davis; Karen K Biron; Leroy B Townsend; John C Drach
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

Review 2.  In search of effective anti-HHV-6 agents.

Authors:  Erik De Clercq; Lieve Naesens
Journal:  J Clin Virol       Date:  2006-12       Impact factor: 3.168

Review 3.  Emerging viral infections after hematopoietic cell transplantation.

Authors:  Michael Boeckh; Veronique Erard; Danielle Zerr; Janet Englund
Journal:  Pediatr Transplant       Date:  2005-12

4.  Anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl] x guanine (A-5021) in vitro and in vivo.

Authors:  J Neyts; L Naesens; C Ying; L De Bolle; E De Clercq
Journal:  Antiviral Res       Date:  2001-02       Impact factor: 5.970

Review 5.  Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8.

Authors:  E De Clercq; L Naesens; L De Bolle; D Schols; Y Zhang; J Neyts
Journal:  Rev Med Virol       Date:  2001 Nov-Dec       Impact factor: 6.989

6.  Synthesis and antiviral evaluation of halogenated beta-D- and -L-erythrofuranosylbenzimidazoles.

Authors:  K S Gudmundsson; J Tidwell; N Lippa; G W Koszalka; N van Draanen; R G Ptak; J C Drach; L B Townsend
Journal:  J Med Chem       Date:  2000-06-15       Impact factor: 7.446

7.  Effectiveness of ganciclovir against human herpesvirus-6 excreted in saliva in stem cell transplant recipients.

Authors:  P Ljungman; H Dahl; Y-H Xu; K Larsson; M Brytting; A Linde
Journal:  Bone Marrow Transplant       Date:  2007-03-05       Impact factor: 5.483

8.  Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses.

Authors:  Lieve Naesens; Chad E Stephens; Graciela Andrei; Arianna Loregian; Leen De Bolle; Robert Snoeck; J Walter Sowell; Erik De Clercq
Journal:  Antiviral Res       Date:  2006-04-18       Impact factor: 5.970

9.  Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes.

Authors:  Mark N Prichard; Elizabeth Sztul; Shannon L Daily; Amie L Perry; Samuel L Frederick; Rachel B Gill; Caroll B Hartline; Daniel N Streblow; Susan M Varnum; Richard D Smith; Earl R Kern
Journal:  J Virol       Date:  2008-03-05       Impact factor: 5.103

10.  Viral and cell cycle-regulated kinases in cytomegalovirus-induced pseudomitosis and replication.

Authors:  Laura Hertel; Sunwen Chou; Edward S Mocarski
Journal:  PLoS Pathog       Date:  2007-01       Impact factor: 6.823
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  6 in total

1.  Maribavir inhibits Epstein-Barr virus transcription through the EBV protein kinase.

Authors:  Christopher B Whitehurst; Marcia K Sanders; Mankit Law; Fu-Zhang Wang; Jie Xiong; Dirk P Dittmer; Joseph S Pagano
Journal:  J Virol       Date:  2013-02-28       Impact factor: 5.103

2.  Applications of ortho-phenylisonitrile and ortho-N-Boc aniline for the two-step preparation of novel bis-heterocyclic chemotypes.

Authors:  Zhigang Xu; Arthur Y Shaw; Gary S Nichol; Alexandra P Cappelli; Christopher Hulme
Journal:  Mol Divers       Date:  2012-05-24       Impact factor: 2.943

Review 3.  The development of new therapies for human herpesvirus 6.

Authors:  Mark N Prichard; Richard J Whitley
Journal:  Curr Opin Virol       Date:  2014-10-22       Impact factor: 7.090

4.  Synthesis and antiviral activities of methylenecyclopropane analogs with 6-alkoxy and 6-alkylthio substitutions that exhibit broad-spectrum antiviral activity against human herpesviruses.

Authors:  Mark N Prichard; John D Williams; Gloria Komazin-Meredith; Atiyya R Khan; Nathan B Price; Geraldine M Jefferson; Emma A Harden; Caroll B Hartline; Norton P Peet; Terry L Bowlin
Journal:  Antimicrob Agents Chemother       Date:  2013-05-13       Impact factor: 5.191

5.  Human herpesvirus 6 U69 kinase phosphorylates the methylenecyclopropane nucleosides cyclopropavir, MBX 2168, and MBX 1616 to their monophosphates.

Authors:  Gloria Komazin-Meredith; Steven C Cardinale; John D Williams; Norton P Peet; Mark N Prichard; Terry L Bowlin
Journal:  Antimicrob Agents Chemother       Date:  2013-08-26       Impact factor: 5.191

6.  In silico DFT study, molecular docking, and ADMET predictions of cytidine analogs with antimicrobial and anticancer properties.

Authors:  Kazi M Rana; Jannatul Maowa; Asraful Alam; Sujan Dey; Anowar Hosen; Imtiaj Hasan; Yuki Fujii; Yasuhiro Ozeki; Sarkar M A Kawsar
Journal:  In Silico Pharmacol       Date:  2021-07-06
  6 in total

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