| Literature DB >> 33436584 |
Ya Cao1,2,3,4,5,6,7, Longlong Xie8,9,10, Feng Shi8,9,10, Min Tang8,9,10,11, Yueshuo Li8,9,10, Jianmin Hu8,9,10, Lin Zhao8,9,10, Luqing Zhao8, Xinfang Yu8,9,10, Xiangjian Luo8,9,10,11, Weihua Liao12, Ann M Bode13.
Abstract
Epstein-Barr virus-associated diseases are important global health concerns. As a group I carcinogen, EBV accounts for 1.5% of human malignances, including both epithelial- and lymphatic-originated tumors. Moreover, EBV plays an etiological and pathogenic role in a number of non-neoplastic diseases, and is even involved in multiple autoimmune diseases (SADs). In this review, we summarize and discuss some recent exciting discoveries in EBV research area, which including DNA methylation alterations, metabolic reprogramming, the changes of mitochondria and ubiquitin-proteasome system (UPS), oxidative stress and EBV lytic reactivation, variations in non-coding RNA (ncRNA), radiochemotherapy and immunotherapy. Understanding and learning from this advancement will further confirm the far-reaching and future value of therapeutic strategies in EBV-associated diseases.Entities:
Mesh：
Year: 2021 PMID： 33436584 PMCID： PMC7801793 DOI： 10.1038/s41392-020-00376-4
Source DB: PubMed Journal: Signal Transduct Target Ther ISSN： 2059-3635