Literature DB >> 9877179

A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25.

S Noto1, T Maeda, S Hattori, J Inazawa, M Imamura, M Asaka, M Hatakeyama.   

Abstract

We report the molecular cloning of a human cDNA that encodes a molecule having striking homology with Ras-specific GTPase-activating proteins (RasGAPs). Among previously described RasGAPs, the cDNA product is most closely related to Caenorhabditis elegans GAP-2, including a predicted coiled-coil structure near the carboxyl terminus. Expression of the cDNA in Saccharomyces cerevisiae defective in one of two RasGAPs, Ira2, complemented loss of the Ira2 function, indicating that the cDNA product functions as a RasGAP. The RasGAP-like gene is located on the human chromosome 1q25, the locus that appears to contain a hereditary prostate cancer susceptible gene, HPC1.

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Year:  1998        PMID： 9877179     DOI： 10.1016/s0014-5793(98)01530-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction.

Authors:  Vladimir Pena; Michael Hothorn; Alexander Eberth; Nikolai Kaschau; Annabel Parret; Lothar Gremer; Fabien Bonneau; Mohammad Reza Ahmadian; Klaus Scheffzek
Journal:  EMBO Rep       Date:  2008-03-07       Impact factor: 8.807

Review 2.  Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis.

Authors:  Philip D King; Beth A Lubeck; Philip E Lapinski
Journal:  Sci Signal       Date:  2013-02-26       Impact factor: 8.192

3.  The A2A adenosine receptor is a dual coding gene: a novel mechanism of gene usage and signal transduction.

Authors:  Chien-fei Lee; Hsin-Lin Lai; Yi-Chao Lee; Chen-Li Chien; Yijuang Chern
Journal:  J Biol Chem       Date:  2013-11-29       Impact factor: 5.157

4.  Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders.

Authors:  Xiaoqiang Zhu; Simin Xie; Tian Xu; Xiaohui Wu; Min Han
Journal:  Mol Metab       Date:  2017-03-18       Impact factor: 7.422

5.  Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila.

Authors:  Qanber Raza; Jae Young Choi; Yang Li; Roisin M O'Dowd; Simon C Watkins; Maria Chikina; Yang Hong; Nathan L Clark; Adam V Kwiatkowski
Journal:  PLoS Genet       Date:  2019-02-14       Impact factor: 5.917

6.  miR‑654‑3p suppresses cell viability and promotes apoptosis by targeting RASAL2 in non‑small‑cell lung cancer.

Authors:  Jie Xiong; Shigang Xing; Zheng Dong; Lei Niu; Qinghua Xu; Yusheng Li; Pingyi Liu; Peixia Yang
Journal:  Mol Med Rep       Date:  2020-12-10       Impact factor: 2.952

7.  RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial-mesenchymal transition via MAPK/SOX2 pathway in bladder cancer.

Authors:  Ke Hui; Yang Gao; Jun Huang; Shan Xu; Bin Wang; Jin Zeng; Jinhai Fan; Xinyang Wang; Yangyang Yue; Shiqi Wu; Jer-Tsong Hsieh; Dalin He; Kaijie Wu
Journal:  Cell Death Dis       Date:  2017-02-09       Impact factor: 8.469
  7 in total

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