Literature DB >> 23440608

Silicon detectors for combined MR-PET and MR-SPECT imaging.

A Studen1, E Chesi, V Cindro, N H Clinthorne, E Cochran, B Grošičar, M Grkovski, K Honscheid, H Kagan, C Lacasta, G Llosa, M Mikuž, V Stankova, P Weilhammer, D Zontar.   

Abstract

Silicon based devices can extend PET-MR and SPECT-MR imaging to applications, where their advantages in performance outweigh benefits of high statistical counts.Silicon is in many ways an excellent detector material with numerous advantages, among others: excellent energy and spatial resolution, mature processing technology, large signal to noise ratio, relatively low price, availability, versatility and malleability. The signal in silicon is also immune to effects of magnetic field at the level normally used in MR devices. Tests in fields up to 7 T were performed in a study to determine effects of magnetic field on positron range in a silicon PET device. The curvature of positron tracks in direction perpendicular to the field's orientation shortens the distance between emission and annihilation point of the positron. The effect can be fully appreciated for a rotation of the sample for a fixed field direction, compressing range in all dimensions. A popular Ga-68 source was used showing a factor of 2 improvement in image noise compared to zero field operation. There was also a little increase in noise as the reconstructed resolution varied between 2.5 and 1.5 mm.A speculative applications can be recognized in both emission modalities, SPECT and PET.Compton camera is a subspecies of SPECT, where a silicon based scatter as a MR compatible part could inserted into the MR bore and the secondary detector could operate in less constrained environment away from the magnet. Introducing a Compton camera also relaxes requirements of the radiotracers used, extending the range of conceivable photon energies beyond 140.5 keV of the Tc-99m.In PET, one could exploit the compressed sub-millimeter range of positrons in the magnetic field. To exploit the advantage, detectors with spatial resolution commensurate to the effect must be used with silicon being an excellent candidate. Measurements performed outside of the MR achieving spatial resolution below 1 mm are reported.

Entities:  

Keywords:  PET; silicon detectors

Year:  2012        PMID: 23440608      PMCID: PMC3578311          DOI: 10.1016/j.nima.2012.08.040

Source DB:  PubMed          Journal:  Nucl Instrum Methods Phys Res A        ISSN: 0168-9002            Impact factor:   1.455


  1 in total

1.  Silicon as an Unconventional Detector in Positron Emission Tomography.

Authors:  N H Clinthorne; K Brzezinski; E Chesi; E Cochran; M Grkovski; B Grošičar; K Honscheid; S Huh; H Kagan; C Lacasta; V Linhart; M Mikuž; S Smith; V Stankova; A Studen; P Weilhammer; D Zontar
Journal:  Nucl Instrum Methods Phys Res A       Date:  2012-05-14       Impact factor: 1.455

  1 in total
  3 in total

1.  Image reconstruction and system modeling techniques for virtual-pinhole PET insert systems.

Authors:  Daniel B Keesing; Aswin Mathews; Sergey Komarov; Heyu Wu; Tae Yong Song; Joseph A O'Sullivan; Yuan-Chuan Tai
Journal:  Phys Med Biol       Date:  2012-04-11       Impact factor: 3.609

2.  A multiscale X-ray phase-contrast tomography dataset of a whole human left lung.

Authors:  R Patrick Xian; Paul Tafforeau; Claire L Walsh; Stijn E Verleden; Willi L Wagner; Alexandre Bellier; Sebastian Marussi; Maximilian Ackermann; Danny D Jonigk; Joseph Jacob; Peter D Lee
Journal:  Sci Data       Date:  2022-06-02       Impact factor: 8.501

3.  Evaluation of a high resolution silicon PET insert module.

Authors:  Milan Grkovski; Karol Brzezinski; Vladimir Cindro; Neal H Clinthorne; Harris Kagan; Carlos Lacasta; Marko Mikuž; Carles Solaz; Andrej Studen; Peter Weilhammer; Dejan Žontar
Journal:  Nucl Instrum Methods Phys Res A       Date:  2015-04-08       Impact factor: 1.455

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.