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Literature DB >> 23437435

A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders.

Kimberly M Lincoln¹, Paulina Gonzalez, Timothy E Richardson, David A Julovich, Ryker Saunders, James W Simpkins, Kayla N Green.

Abstract

Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2013 PMID： 23437435 PMCID： PMC4446701 DOI： 10.1039/c2cc36808k

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

22 in total

Review 1. Oxidative stress in neurodegeneration: cause or consequence?

Authors: Julie K Andersen
Journal: Nat Med Date: 2004-07 Impact factor: 53.440

2. Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer's disease.

Authors: Lauren E Scott; Brent D G Page; Brian O Patrick; Chris Orvig
Journal: Dalton Trans Date: 2008-10-06 Impact factor: 4.390

Review 3. Medicinal inorganic chemistry approaches to passivation and removal of aberrant metal ions in disease.

Authors: Lauren E Scott; Chris Orvig
Journal: Chem Rev Date: 2009-10 Impact factor: 60.622

Review 4. Metals in neurobiology: probing their chemistry and biology with molecular imaging.

Authors: Emily L Que; Dylan W Domaille; Christopher J Chang
Journal: Chem Rev Date: 2008-04-22 Impact factor: 60.622

Review 5. Condensed and hydrolysable tannins as antioxidants influencing the health.

Authors: Vit Koleckar; Katerina Kubikova; Zuzana Rehakova; Kamil Kuca; Daniel Jun; Ludek Jahodar; Lubomir Opletal
Journal: Mini Rev Med Chem Date: 2008-05 Impact factor: 3.862

6. Chemical pathway and kinetics of phenol oxidation by Fenton's reagent.

Authors: J A Zazo; J A Casas; A F Mohedano; M A Gilarranz; J J Rodríguez
Journal: Environ Sci Technol Date: 2005-12-01 Impact factor: 9.028

Review 7. Therapeutics for Alzheimer's disease based on the metal hypothesis.

Authors: Ashley I Bush; Rudolph E Tanzi
Journal: Neurotherapeutics Date: 2008-07 Impact factor: 7.620

Review 8. Copper in the brain and Alzheimer's disease.

Authors: Ya Hui Hung; Ashley I Bush; Robert Alan Cherny
Journal: J Biol Inorg Chem Date: 2009-10-28 Impact factor: 3.358

9. Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.

Authors: Paul A Adlard; Robert A Cherny; David I Finkelstein; Elisabeth Gautier; Elysia Robb; Mikhalina Cortes; Irene Volitakis; Xiang Liu; Jeffrey P Smith; Keyla Perez; Katrina Laughton; Qiao-Xin Li; Susan A Charman; Joseph A Nicolazzo; Simon Wilkins; Karolina Deleva; Toni Lynch; Gaik Kok; Craig W Ritchie; Rudolph E Tanzi; Roberto Cappai; Colin L Masters; Kevin J Barnham; Ashley I Bush
Journal: Neuron Date: 2008-07-10 Impact factor: 17.173

Review 10. Abeta-mediated ROS production by Cu ions: structural insights, mechanisms and relevance to Alzheimer's disease.

Authors: Christelle Hureau; Peter Faller
Journal: Biochimie Date: 2009-03-28 Impact factor: 4.079

15 in total

1. Dialing in on pharmacological features for a therapeutic antioxidant small molecule.

Authors: Kayla N Green; Kristof Pota; Gyula Tircsó; Réka Anna Gogolák; Olivia Kinsinger; Collin Davda; Kimberly Blain; Samantha M Brewer; Paulina Gonzalez; Hannah M Johnston; Giridhar Akkaraju
Journal: Dalton Trans Date: 2019-07-25 Impact factor: 4.390

2. Enhancement of the Antioxidant Activity and Neurotherapeutic Features through Pyridol Addition to Tetraazamacrocyclic Molecules.

Authors: Hannah M Johnston; Kristof Pota; Madalyn M Barnett; Olivia Kinsinger; Paige Braden; Timothy M Schwartz; Emily Hoffer; Nishanth Sadagopan; Nam Nguyen; Yu Yu; Paulina Gonzalez; Gyula Tircsó; Hongli Wu; Giridhar Akkaraju; Michael J Chumley; Kayla N Green
Journal: Inorg Chem Date: 2019-11-27 Impact factor: 5.165

3. Bimodal-hybrid heterocyclic amine targeting oxidative pathways and copper mis-regulation in Alzheimer's disease.

Authors: Paulina Gonzalez; Viviana C P da Costa; Kimberly Hyde; Qiong Wu; Onofrio Annunziata; Josep Rizo; Giridhar Akkaraju; Kayla N Green
Journal: Metallomics Date: 2014-11 Impact factor: 4.526

4. Electronic influence of substitution on the pyridine ring within NNN pincer-type molecules.

Authors: Timothy M Schwartz; Marianne E Burnett; Kayla N Green
Journal: Dalton Trans Date: 2020-02-05 Impact factor: 4.390

5. Fraxin Alleviates LPS-Induced ARDS by Downregulating Inflammatory Responses and Oxidative Damages and Reducing Pulmonary Vascular Permeability.

Authors: Xiaohong Ma; Xiangyong Liu; Jiali Feng; Dong Zhang; Lina Huang; Dongxiao Li; Liang Yin; Lan Li; Xiao-Zhi Wang
Journal: Inflammation Date: 2019-10 Impact factor: 4.092