Literature DB >> 19002321

Altering pyridinone N-substituents to optimise activity as potential prodrugs for Alzheimer's disease.

Lauren E Scott1, Brent D G Page, Brian O Patrick, Chris Orvig.   

Abstract

Selective design modifications of specifically substituted 3-hydroxy-4(1H)-pyridinones show possibly advantageous ring freedom while maintaining metal-binding ability and antioxidant capacity, moving toward an efficient potential treatment for Alzheimer's disease.

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Year:  2008        PMID： 19002321     DOI： 10.1039/b815404j

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  7 in total

1.  A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders.

Authors:  Kimberly M Lincoln; Paulina Gonzalez; Timothy E Richardson; David A Julovich; Ryker Saunders; James W Simpkins; Kayla N Green
Journal:  Chem Commun (Camb)       Date:  2013-04-04       Impact factor: 6.222

2.  Enzymatic activation of a matrix metalloproteinase inhibitor.

Authors:  Jody L Major Jourden; Seth M Cohen
Journal:  Chem Commun (Camb)       Date:  2010-01-18       Impact factor: 6.222

Review 3.  Emerging trends in metalloprotein inhibition.

Authors:  Matthieu Rouffet; Seth M Cohen
Journal:  Dalton Trans       Date:  2011-02-02       Impact factor: 4.390

4.  Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.

Authors:  Lissette R Perez; Katherine J Franz
Journal:  Dalton Trans       Date:  2009-12-17       Impact factor: 4.390

5.  An N-heterocyclic amine chelate capable of antioxidant capacity and amyloid disaggregation.

Authors:  Kimberly M Lincoln; Timothy E Richardson; Lauren Rutter; Paulina Gonzalez; James W Simpkins; Kayla N Green
Journal:  ACS Chem Neurosci       Date:  2012-08-31       Impact factor: 4.418

6.  2-Ethyl-3-hy-droxy-1-isopropyl-4-pyridone.

Authors:  Pule P Molokoane; M Schutte; G Steyl
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-10-27

Review 7.  Copper Toxicity Links to Pathogenesis of Alzheimer's Disease and Therapeutics Approaches.

Authors:  Hafza Wajeeha Ejaz; Wei Wang; Minglin Lang
Journal:  Int J Mol Sci       Date:  2020-10-16       Impact factor: 5.923
  7 in total

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