Literature DB >> 23436701

Mass spectrometry-based methods to study protein architecture and dynamics.

Igor A Kaltashov1, Cedric E Bobst, Rinat R Abzalimov.   

Abstract

Mass spectrometry is now an indispensable tool in the armamentarium of molecular biophysics, where it is used for tasks ranging from protein sequencing and mapping of post-translational modifications to studies of higher order structure, conformational dynamics, and interactions of proteins with small molecule ligands and other biopolymers. This mini-review highlights several popular mass spectrometry-based tools that are now commonly used for structural studies of proteins beyond their covalent structure with a particular emphasis on hydrogen exchange and direct electrospray ionization mass spectrometry.
Copyright © 2013 The Protein Society.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23436701      PMCID： PMC3649255          DOI： 10.1002/pro.2238

Source DB:  PubMed          Journal:  Protein Sci        ISSN： 0961-8368            Impact factor:   6.725


  73 in total

1.  Mapping of discontinuous conformational epitopes by amide hydrogen/deuterium exchange mass spectrometry and computational docking.

Authors:  Deepangi Pandit; Steven J Tuske; Stephen J Coales; Sook Yen E; Anita Liu; Jessica E Lee; Jeffrey A Morrow; Jennifer F Nemeth; Yoshitomo Hamuro
Journal:  J Mol Recognit       Date:  2012-03       Impact factor: 2.137

2.  Electrospray ionization mass spectrometry of highly heterogeneous protein systems: protein ion charge state assignment via incomplete charge reduction.

Authors:  Rinat R Abzalimov; Igor A Kaltashov
Journal:  Anal Chem       Date:  2010-09-15       Impact factor: 6.986

3.  Do ionic charges in ESI MS provide useful information on macromolecular structure?

Authors:  Igor A Kaltashov; Rinat R Abzalimov
Journal:  J Am Soc Mass Spectrom       Date:  2008-07-03       Impact factor: 3.109

4.  Post-translational modifications differentially affect IgG1 conformation and receptor binding.

Authors:  Damian Houde; Yucai Peng; Steven A Berkowitz; John R Engen
Journal:  Mol Cell Proteomics       Date:  2010-01-26       Impact factor: 5.911

5.  Characterization of intrinsically disordered proteins with electrospray ionization mass spectrometry: conformational heterogeneity of alpha-synuclein.

Authors:  Agya K Frimpong; Rinat R Abzalimov; Vladimir N Uversky; Igor A Kaltashov
Journal:  Proteins       Date:  2010-02-15

Review 6.  Advanced mass spectrometry-based methods for the analysis of conformational integrity of biopharmaceutical products.

Authors:  Cedric E Bobst; Igor A Kaltashov
Journal:  Curr Pharm Biotechnol       Date:  2011-10       Impact factor: 2.837

7.  IL-1beta epitope mapping using site-directed mutagenesis and hydrogen-deuterium exchange mass spectrometry analysis.

Authors:  Jirong Lu; Derrick R Witcher; Melissa A White; Xiliang Wang; Lihua Huang; Radhakrishnan Rathnachalam; John M Beals; Stuart Kuhstoss
Journal:  Biochemistry       Date:  2005-08-23       Impact factor: 3.162

8.  Conformation and dynamics of biopharmaceuticals: transition of mass spectrometry-based tools from academe to industry.

Authors:  Igor A Kaltashov; Cedric E Bobst; Rinat R Abzalimov; Steven A Berkowitz; Damian Houde
Journal:  J Am Soc Mass Spectrom       Date:  2009-10-29       Impact factor: 3.109

9.  H/D exchange and mass spectrometry in the studies of protein conformation and dynamics: is there a need for a top-down approach?

Authors:  Igor A Kaltashov; Cedric E Bobst; Rinat R Abzalimov
Journal:  Anal Chem       Date:  2009-10-01       Impact factor: 6.986

10.  Determination of the mechanism of action of anti-FasL antibody by epitope mapping and homology modeling.

Authors:  Victor H Obungu; Valentina Gelfanova; Radhakrishnan Rathnachalam; Anna Bailey; Joanne Sloan-Lancaster; Lihua Huang
Journal:  Biochemistry       Date:  2009-08-04       Impact factor: 3.162
View more
  29 in total

1.  Load-dependent destabilization of the γ-rotor shaft in FOF1 ATP synthase revealed by hydrogen/deuterium-exchange mass spectrometry.

Authors:  Siavash Vahidi; Yumin Bi; Stanley D Dunn; Lars Konermann
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-16       Impact factor: 11.205

2.  Conformer-specific characterization of nonnative protein states using hydrogen exchange and top-down mass spectrometry.

Authors:  Guanbo Wang; Rinat R Abzalimov; Cedric E Bobst; Igor A Kaltashov
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-25       Impact factor: 11.205

Review 3.  Mass spectrometry in studies of protein thiol chemistry and signaling: opportunities and caveats.

Authors:  Nelmi O Devarie Baez; Julie A Reisz; Cristina M Furdui
Journal:  Free Radic Biol Med       Date:  2014-09-28       Impact factor: 7.376

4.  Electron-capture dissociation and ion mobility mass spectrometry for characterization of the hemoglobin protein assembly.

Authors:  Weidong Cui; Hao Zhang; Robert E Blankenship; Michael L Gross
Journal:  Protein Sci       Date:  2015-07-15       Impact factor: 6.725

5.  Protein structural dynamics at the gas/water interface examined by hydrogen exchange mass spectrometry.

Authors:  Yiming Xiao; Lars Konermann
Journal:  Protein Sci       Date:  2015-04-02       Impact factor: 6.725

Review 6.  Are Charge-State Distributions a Reliable Tool Describing Molecular Ensembles of Intrinsically Disordered Proteins by Native MS?

Authors:  Antonino Natalello; Carlo Santambrogio; Rita Grandori
Journal:  J Am Soc Mass Spectrom       Date:  2016-10-11       Impact factor: 3.109

7.  Protein hydrogen exchange at residue resolution by proteolytic fragmentation mass spectrometry analysis.

Authors:  Zhong-Yuan Kan; Benjamin T Walters; Leland Mayne; S Walter Englander
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-09       Impact factor: 11.205

8.  Crucial role of perfringolysin O D1 domain in orchestrating structural transitions leading to membrane-perforating pores: a hydrogen-deuterium exchange study.

Authors:  Aleksandra Kacprzyk-Stokowiec; Magdalena Kulma; Gabriela Traczyk; Katarzyna Kwiatkowska; Andrzej Sobota; Michał Dadlez
Journal:  J Biol Chem       Date:  2014-08-27       Impact factor: 5.157

Review 9.  Mass spectrometry-based methods in characterization of the higher order structure of protein therapeutics.

Authors:  Igor A Kaltashov; Cedric E Bobst; Jake Pawlowski; Guanbo Wang
Journal:  J Pharm Biomed Anal       Date:  2020-02-12       Impact factor: 3.935

Review 10.  Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies.

Authors:  Hao Zhang; Weidong Cui; Michael L Gross
Journal:  FEBS Lett       Date:  2013-11-26       Impact factor: 4.124
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.