| Literature DB >> 23436135 |
Renata da Silva Pereira1, Etiane Tatsch, Guilherme Vargas Bochi, Helena Kober, Thiago Duarte, Greice Franciele Feyh dos Santos Montagner, José Edson Paz da Silva, Marta Maria Medeiros Frescura Duarte, Ivana Beatrice Mânica da Cruz, Rafael Noal Moresco.
Abstract
The aim of this study was to assess the levels of oxidative, inflammatory, and fibrinolytic biomarkers as well as DNA strand breakage in hypercholesterolemic subjects. Fasting glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, uric acid, total protein, albumin, apolipoprotein (Apo) A, Apo B, advanced oxidation protein products (AOPP), increased ischemia-modified albumin (IMA), -SH, NOx, IL-6, and D-dimer levels were assessed, and DNA strand breakage was evaluated using comet assay in 38 patients with hypercholesterolemia and 20 healthy controls. Total cholesterol, triglycerides, LDL cholesterol, Apo A, Apo B, AOPP, IMA, IL-6, and D-dimer concentrations were significantly higher in subjects with hypercholesterolemia. However, NOx and plasma -SH group concentrations were lower in hypercholesterolemic subjects, while no significant differences were observed with respect to DNA strand breakage between the two groups. Hypercholesterolemia is related to oxidative stress and inflammation. Accordingly, AOPP concentration was higher in subjects with hypercholesterolemia, and we speculate that AOPP can reflect the enhancement of protein oxidation and inflammation.Entities:
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Year: 2013 PMID： 23436135 DOI： 10.1007/s10753-013-9614-2
Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092