| Literature DB >> 23418022 |
Miriam Seitz1, Per-Olof Syrén, Lisa Steiner, Janosch Klebensberger, Bettina M Nestl, Bernhard Hauer.
Abstract
PROMISCUOUS ENZYMES: The substrate promiscuity of squalene-hopene cyclases has been explored and applied in the enzyme-catalyzed synthesis of heterocyclic terpenoids. Features of this work include cyclization reactions without pyrophosphate activation, and stereospecific ring closure of substrates of varying chain length and terminal nucleophile. This provides a biocatalytic alternative to traditional chemical catalysts.Entities:
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Year: 2013 PMID： 23418022 DOI： 10.1002/cbic.201300018
Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164