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Literature DB >> 23416453

Design of a platinum-acridine-endoxifen conjugate targeted at hormone-dependent breast cancer.

Song Ding¹, Xin Qiao, Gregory L Kucera, Ulrich Bierbach.

Abstract

The synthesis of a novel pharmacophore comprising a DNA-targeted platinum-acridine hybrid agent and estrogen receptor-targeted 4-hydroxy-N-desmethyltamoxifen (endoxifen) using carbamate coupling chemistry and its evaluation in breast cancer cell lines are described.

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Year: 2013 PMID： 23416453 PMCID： PMC3606895 DOI： 10.1039/c3cc38957j

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

23 in total

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Authors: Rongsheng E Wang; Frankie Costanza; Youhong Niu; Haifan Wu; Yaogang Hu; Whitney Hang; Yiqun Sun; Jianfeng Cai
Journal: J Control Release Date: 2011-12-01 Impact factor: 9.776

2. Analysis of the DNA damage produced by a platinum-acridine antitumor agent and its effects in NCI-H460 lung cancer cells.

Authors: Xin Qiao; Alexandra E Zeitany; Marcus W Wright; Amal S Essader; Keith E Levine; Gregory L Kucera; Ulrich Bierbach
Journal: Metallomics Date: 2012-03-29 Impact factor: 4.526

Review 3. Antibody-drug conjugates: targeted drug delivery for cancer.

Authors: Stephen C Alley; Nicole M Okeley; Peter D Senter
Journal: Curr Opin Chem Biol Date: 2010-07-17 Impact factor: 8.822

Review 4. Biological determinants of endocrine resistance in breast cancer.

Authors: Elizabeth A Musgrove; Robert L Sutherland
Journal: Nat Rev Cancer Date: 2009-09 Impact factor: 60.716

5. Replacement of a thiourea with an amidine group in a monofunctional platinum-acridine antitumor agent. Effect on DNA interactions, DNA adduct recognition and repair.

Authors: Hana Kostrhunova; Jaroslav Malina; Amanda J Pickard; Jana Stepankova; Marie Vojtiskova; Jana Kasparkova; Tereza Muchova; Matthew L Rohlfing; Ulrich Bierbach; Viktor Brabec
Journal: Mol Pharm Date: 2011-08-17 Impact factor: 4.939

6. Selective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cells.

Authors: Kuan-Wei Peng; Huali Wang; Zhihui Qin; Gihani T Wijewickrama; Meiling Lu; Zhican Wang; Judy L Bolton; Gregory R J Thatcher
Journal: ACS Chem Biol Date: 2009-12-18 Impact factor: 5.100

7. Design, synthesis, and biological evaluation of doxorubicin-formaldehyde conjugates targeted to breast cancer cells.

Authors: Patrick J Burke; Tad H Koch
Journal: J Med Chem Date: 2004-02-26 Impact factor: 7.446

8. The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.

Authors: A K Shiau; D Barstad; P M Loria; L Cheng; P J Kushner; D A Agard; G L Greene
Journal: Cell Date: 1998-12-23 Impact factor: 41.582

Review 9. Platinum-based chemotherapy in metastatic breast cancer: current status.

Authors: M P Decatris; S Sundar; K J O'Byrne
Journal: Cancer Treat Rev Date: 2004-02 Impact factor: 12.111

Review 10. Relevance of breast cancer cell lines as models for breast tumours: an update.

Authors: Marc Lacroix; Guy Leclercq
Journal: Breast Cancer Res Treat Date: 2004-02 Impact factor: 4.872

4 in total

1. Design and cellular studies of a carbon nanotube-based delivery system for a hybrid platinum-acridine anticancer agent.

Authors: Cale D Fahrenholtz; Song Ding; Brian W Bernish; Mariah L Wright; Ye Zheng; Mu Yang; Xiyuan Yao; George L Donati; Michael D Gross; Ulrich Bierbach; Ravi Singh
Journal: J Inorg Biochem Date: 2016-07-27 Impact factor: 4.155