| Literature DB >> 27496614 |
Cale D Fahrenholtz1, Song Ding2, Brian W Bernish3, Mariah L Wright4, Ye Zheng5, Mu Yang6, Xiyuan Yao7, George L Donati8, Michael D Gross9, Ulrich Bierbach10, Ravi Singh11.
Abstract
A three-component drug-delivery system has been developed consisting of multi-walled carbon nanotubes (MWCNTs) coated with a non-classical platinum chemotherapeutic agent ([PtCl(NH3)2(L)]Cl (P3A1; L=N-(2-(acridin-9-ylamino)ethyl)-N-methylproprionimidamide) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-5000] (DSPE-mPEG). The optimized P3A1-MWCNTs are colloidally stable in physiological solution and deliver more P3A1 into breast cancer cells than treatment with the free drug. Furthermore, P3A1-MWCNTs are cytotoxic to several cell models of breast cancer and induce S-phase cell cycle arrest and non-apoptotic cell death in breast cancer cells. By contrast, free P3A1 induces apoptosis and allows progression to G2/M phase. Photothermal activation of P3A1-MWCNTs to generate mild hyperthermia potentiates their cytotoxicity. These findings suggest that delivery of P3A1 to cancer cells using MWCNTs as a drug carrier may be beneficial for combination cancer chemotherapy and photothermal therapy.Entities:
Keywords: Chemotherapy; Cytotoxicity; Drug delivery; Nanoparticle; Photothermal therapy; Triple negative breast cancer
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Year: 2016 PMID： 27496614 PMCID： PMC5154932 DOI： 10.1016/j.jinorgbio.2016.07.016
Source DB: PubMed Journal: J Inorg Biochem ISSN： 0162-0134 Impact factor: 4.155