PURPOSE: To quantify set-up uncertainties during voluntary deep inspiration breath hold (DIBH) radiotherapy using 3D-surface imaging in patients with left sided breast cancer. MATERIAL AND METHODS: Nineteen patients were included. Cone-beam CT-scan (CBCT) was used for online set-up correction while patients were instructed to perform a voluntary DIBH. The reproducibility of the DIBH during treatment was monitored with 2D-fluoroscopy and portal imaging. Simultaneously, a surface imaging system was used to capture 3D-surfaces throughout CBCT acquisition and delivery of treatment beams. Retrospectively, all captured surfaces were registered to the planning-CT surface. Interfraction, intra-fraction and intra-beam set-up variability were quantified in left-right, cranio-caudal and anterior-posterior direction. RESULTS: Inter-fraction systematic (Σ) and random (σ) translational errors (1SD) before and after set-up correction were between 0.20-0.50 cm and 0.09-0.22 cm, respectively, whereas rotational Σ and σ errors were between 0.08 and 1.56°. The intra-fraction Σ and σ errors were ≤ 0.14 cm and ≤ 0.47°. The intra-beam SD variability was ≤ 0.08 cm and ≤ 0.28° in all directions. CONCLUSION: Quantification of 3D set-up variability in DIBH RT showed that patients are able to perform a very stable and reproducible DIBH within a treatment fraction. However, relatively large inter-fraction variability requires online image guided set-up corrections.
PURPOSE: To quantify set-up uncertainties during voluntary deep inspiration breath hold (DIBH) radiotherapy using 3D-surface imaging in patients with left sided breast cancer. MATERIAL AND METHODS: Nineteen patients were included. Cone-beam CT-scan (CBCT) was used for online set-up correction while patients were instructed to perform a voluntary DIBH. The reproducibility of the DIBH during treatment was monitored with 2D-fluoroscopy and portal imaging. Simultaneously, a surface imaging system was used to capture 3D-surfaces throughout CBCT acquisition and delivery of treatment beams. Retrospectively, all captured surfaces were registered to the planning-CT surface. Interfraction, intra-fraction and intra-beam set-up variability were quantified in left-right, cranio-caudal and anterior-posterior direction. RESULTS: Inter-fraction systematic (Σ) and random (σ) translational errors (1SD) before and after set-up correction were between 0.20-0.50 cm and 0.09-0.22 cm, respectively, whereas rotational Σ and σ errors were between 0.08 and 1.56°. The intra-fraction Σ and σ errors were ≤ 0.14 cm and ≤ 0.47°. The intra-beam SD variability was ≤ 0.08 cm and ≤ 0.28° in all directions. CONCLUSION: Quantification of 3D set-up variability in DIBH RT showed that patients are able to perform a very stable and reproducible DIBH within a treatment fraction. However, relatively large inter-fraction variability requires online image guided set-up corrections.
Authors: Christopher Jensen; Jaime Urribarri; Daniel Cail; Joerg Rottmann; Pankaj Mishra; Tatiana Lingos; Thomas Niedermayr; Ross Berbeco Journal: Med Phys Date: 2014-02 Impact factor: 4.071
Authors: A Gnerucci; M Esposito; A Ghirelli; S Pini; L Paoletti; R Barca; S Fondelli; P Alpi; B Grilli; F Rossi; S Scoccianti; S Russo Journal: Strahlenther Onkol Date: 2022-10-13 Impact factor: 4.033
Authors: Thomas Mulliez; Liv Veldeman; Tom Vercauteren; Werner De Gersem; Bruno Speleers; Annick Van Greveling; Dieter Berwouts; Vincent Remouchamps; Rudy Van den Broecke; Wilfried De Neve Journal: Radiat Oncol Date: 2015-01-09 Impact factor: 3.481
Authors: Marko Laaksomaa; Mika Kapanen; Mikko Haltamo; Tanja Skyttä; Seppo Peltola; Simo Hyödynmaa; Pirkko-Liisa Kellokumpu-Lehtinen Journal: Radiat Oncol Date: 2015-04-03 Impact factor: 3.481