CONTEXT: Neuroimaging studies of brain anatomy in autism spectrum disorder (ASD) have mostly been based on measures of cortical volume (CV). However, CV is a product of 2 distinct parameters, cortical thickness (CT) and surface area (SA), that in turn have distinct genetic and developmental origins. OBJECTIVE: To investigate regional differences in CV, SA, and CT as well as their relationship in a large and well-characterized sample of men with ASD and matched controls. DESIGN: Multicenter case-control design using quantitative magnetic resonance imaging. SETTING: Medical Research Council UK Autism Imaging Multicentre Study. PARTICIPANTS: A total of 168 men, 84 diagnosed as having ASD and 84 controls who did not differ significantly in mean (SD) age (26 [7] years vs 28 [6] years, respectively) or full-scale IQ (110 [14] vs 114 [12], respectively). MAIN OUTCOME MEASURES: Between-group differences in CV, SA, and CT investigated using a spatially unbiased vertex-based approach; the degree of spatial overlap between the differences in CT and SA; and their relative contribution to differences in regional CV. RESULTS: Individuals with ASD differed from controls in all 3 parameters. These mainly consisted of significantly increased CT within frontal lobe regions and reduced SA in the orbitofrontal cortex and posterior cingulum. These differences in CT and SA were paralleled by commensurate differences in CV. The spatially distributed patterns for CT and SA were largely nonoverlapping and shared only about 3% of all significantly different locations on the cerebral surface. CONCLUSIONS: Individuals with ASD have significant differences in CV, but these may be underpinned by (separable) variations in its 2 components, CT and SA. This is of importance because both measures result from distinct developmental pathways that are likely modulated by different neurobiological mechanisms. This finding may provide novel targets for future studies into the etiology of the condition and a new way to fractionate the disorder.
CONTEXT: Neuroimaging studies of brain anatomy in autism spectrum disorder (ASD) have mostly been based on measures of cortical volume (CV). However, CV is a product of 2 distinct parameters, cortical thickness (CT) and surface area (SA), that in turn have distinct genetic and developmental origins. OBJECTIVE: To investigate regional differences in CV, SA, and CT as well as their relationship in a large and well-characterized sample of men with ASD and matched controls. DESIGN: Multicenter case-control design using quantitative magnetic resonance imaging. SETTING: Medical Research Council UK Autism Imaging Multicentre Study. PARTICIPANTS: A total of 168 men, 84 diagnosed as having ASD and 84 controls who did not differ significantly in mean (SD) age (26 [7] years vs 28 [6] years, respectively) or full-scale IQ (110 [14] vs 114 [12], respectively). MAIN OUTCOME MEASURES: Between-group differences in CV, SA, and CT investigated using a spatially unbiased vertex-based approach; the degree of spatial overlap between the differences in CT and SA; and their relative contribution to differences in regional CV. RESULTS: Individuals with ASD differed from controls in all 3 parameters. These mainly consisted of significantly increased CT within frontal lobe regions and reduced SA in the orbitofrontal cortex and posterior cingulum. These differences in CT and SA were paralleled by commensurate differences in CV. The spatially distributed patterns for CT and SA were largely nonoverlapping and shared only about 3% of all significantly different locations on the cerebral surface. CONCLUSIONS: Individuals with ASD have significant differences in CV, but these may be underpinned by (separable) variations in its 2 components, CT and SA. This is of importance because both measures result from distinct developmental pathways that are likely modulated by different neurobiological mechanisms. This finding may provide novel targets for future studies into the etiology of the condition and a new way to fractionate the disorder.
Authors: Christine Ecker; Derek S Andrews; Christina M Gudbrandsen; Andre F Marquand; Cedric E Ginestet; Eileen M Daly; Clodagh M Murphy; Meng-Chuan Lai; Michael V Lombardo; Amber N V Ruigrok; Edward T Bullmore; John Suckling; Steven C R Williams; Simon Baron-Cohen; Michael C Craig; Declan G M Murphy Journal: JAMA Psychiatry Date: 2017-04-01 Impact factor: 21.596
Authors: Covadonga M Díaz-Caneja; Hugo Schnack; Kenia Martínez; Javier Santonja; Yasser Alemán-Gomez; Laura Pina-Camacho; Carmen Moreno; David Fraguas; Celso Arango; Mara Parellada; Joost Janssen Journal: Hum Brain Mapp Date: 2018-12-19 Impact factor: 5.038
Authors: Brandon A Zielinski; Molly B D Prigge; Jared A Nielsen; Alyson L Froehlich; Tracy J Abildskov; Jeffrey S Anderson; P Thomas Fletcher; Kristen M Zygmunt; Brittany G Travers; Nicholas Lange; Andrew L Alexander; Erin D Bigler; Janet E Lainhart Journal: Brain Date: 2014-04-22 Impact factor: 13.501
Authors: Saashi A Bedford; Min Tae M Park; Gabriel A Devenyi; Stephanie Tullo; Jurgen Germann; Raihaan Patel; Evdokia Anagnostou; Simon Baron-Cohen; Edward T Bullmore; Lindsay R Chura; Michael C Craig; Christine Ecker; Dorothea L Floris; Rosemary J Holt; Rhoshel Lenroot; Jason P Lerch; Michael V Lombardo; Declan G M Murphy; Armin Raznahan; Amber N V Ruigrok; Elizabeth Smith; Michael D Spencer; John Suckling; Margot J Taylor; Audrey Thurm; Meng-Chuan Lai; M Mallar Chakravarty Journal: Mol Psychiatry Date: 2019-04-26 Impact factor: 15.992
Authors: Molly B D Prigge; Erin D Bigler; Brittany G Travers; Alyson Froehlich; Tracy Abildskov; Jeffrey S Anderson; Andrew L Alexander; Nicholas Lange; Janet E Lainhart; Brandon A Zielinski Journal: J Autism Dev Disord Date: 2018-10