| Literature DB >> 30511125 |
Charles Laidi1,2,3,4, Jennifer Boisgontier5,6,7, Amicie de Pierrefeu8, Edouard Duchesnay8, Sevan Hotier5,6,7,9, Marc-Antoine d'Albis5,6,7,9, Richard Delorme7,10,11, Federico Bolognani12, Christian Czech12, Céline Bouquet12, Anouck Amestoy13, Julie Petit10, Štefan Holiga12, Juergen Dukart12, Alexandru Gaman5,7,9, Elie Toledano14, Myriam Ly-Le Moal14, Isabelle Scheid5,7,9, Marion Leboyer5,7,9, Josselin Houenou5,6,7,9.
Abstract
Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population.Entities:
Keywords: Adults; Anterior cingulate cortex; Autism; MRI
Mesh：
Year: 2019 PMID： 30511125 DOI： 10.1007/s10803-018-3807-3
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257