| Literature DB >> 29728946 |
Molly B D Prigge1,2,3,4, Erin D Bigler5, Brittany G Travers6,7, Alyson Froehlich8, Tracy Abildskov5, Jeffrey S Anderson9,10, Andrew L Alexander6,11, Nicholas Lange12, Janet E Lainhart6,11, Brandon A Zielinski13,14.
Abstract
The relationship between brain development and clinical heterogeneity in autism (ASD) is unknown. This study examines the Social Responsiveness Scale (SRS) in relation to the longitudinal development of cortical thickness. Participants (N = 91 ASD, N = 56 TDC; 3-39 years at first scan) were scanned up to three times over a 7-year period. Mixed-effects models examined cortical thickness in relation to SRS score. ASD participants with higher SRS scores showed regionally increased age-related cortical thinning. Regional thickness differences and reduced age-related cortical thinning were found in predominantly right lateralized regions in ASD with decreasing SRS scores over time. Our findings emphasize the importance of examining clinical phenotypes in brain-based studies of ASD.Entities:
Keywords: Autism severity; Autism spectrum disorder (ASD); Brain development; Cortical thickness; Longitudinal; Social Responsiveness Scale (SRS)
Mesh：
Year: 2018 PMID： 29728946 PMCID： PMC6143416 DOI： 10.1007/s10803-018-3566-1
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257