Literature DB >> 2340076

The active site and partial sequence of cobra venom acetylcholinesterase.

C Weise1, H J Kreienkamp, R Raba, A Aaviksaar, F Hucho.   

Abstract

About 30% of the primary structure of acetylcholinesterase (AchE) from the cobra Naja naja oxiana has been determined. The sequence around the serine residue labeled by diisopropylfluorophosphate (DFP) was found to be TVTLFGESAGAASVGM which is similar to the active sites of AChE from other tissues. The part of the primary structure determined shows 76% identity with AChE from Torpedo and 42% identity with the Drosophila enzyme. A surprisingly large identity (42% in the sequence determined) was found with lysophospholipase from rat.

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Year:  1990        PMID： 2340076     DOI： 10.1007/bf01024984

Source DB:  PubMed          Journal:  J Protein Chem        ISSN： 0277-8033


  14 in total

1.  Crystallization and preliminary X-ray diffraction analysis of 11 S acetylcholinesterase.

Authors:  J D Schrag; M F Schmid; D G Morgan; G N Phillips; W Chiu; L Tang
Journal:  J Biol Chem       Date:  1988-07-15       Impact factor: 5.157

2.  Cobra venom acetylcholinesterase. Purification and molecular properties.

Authors:  R Raba; A Aaviksaar; M Raba; J Siigur
Journal:  Eur J Biochem       Date:  1979-05-02

3.  Amino acid sequence in the region of the reactive serine residue of eel acetylcholinesterase.

Authors:  N K Schaffer; H O Michel; A F Bridges
Journal:  Biochemistry       Date:  1973-07-17       Impact factor: 3.162

4.  Studies on lysophospholipases. I. Purification and some properties of a lysophospholipase from beef pancreas.

Authors:  H van den Bosch; A J Aarsman; J G de Jong; L L van Deenem
Journal:  Biochim Biophys Acta       Date:  1973-01-19

5.  Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C.

Authors:  J L Sussman; M Harel; F Frolow; L Varon; L Toker; A H Futerman; I Silman
Journal:  J Mol Biol       Date:  1988-10-05       Impact factor: 5.469

6.  Cobra venom acetylcholinesterase: nature of charge isoforms.

Authors:  R Raba; A Aaviksaar
Journal:  Eur J Biochem       Date:  1982-10

7.  Acetylcholinesterase as polyelectrolyte in reaction with cationic substrates.

Authors:  V Tóugu; A Pedak; T Kesvatera; A Aaviksaar
Journal:  FEBS Lett       Date:  1987-12-10       Impact factor: 4.124

8.  Profile of the disulfide bonds in acetylcholinesterase.

Authors:  K MacPhee-Quigley; T S Vedvick; P Taylor; S S Taylor
Journal:  J Biol Chem       Date:  1986-10-15       Impact factor: 5.157

9.  The Ace locus of Drosophila melanogaster: structural gene for acetylcholinesterase with an unusual 5' leader.

Authors:  L M Hall; P Spierer
Journal:  EMBO J       Date:  1986-11       Impact factor: 11.598

10.  cDNA sequences of Torpedo marmorata acetylcholinesterase: primary structure of the precursor of a catalytic subunit; existence of multiple 5'-untranslated regions.

Authors:  J L Sikorav; E Krejci; J Massoulié
Journal:  EMBO J       Date:  1987-07       Impact factor: 11.598
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  5 in total

1.  MTD-ADJ: a multiconformational minimal topologic difference for determining bioactive conformers using adjusted biological activities.

Authors:  T Sulea; L Kurunczi; T I Oprea; Z Simon
Journal:  J Comput Aided Mol Des       Date:  1998-03       Impact factor: 3.686

2.  Two invertebrate acetylcholinesterases show activation followed by inhibition with substrate concentration.

Authors:  V Marcel; L G Palacios; C Pertuy; P Masson; D Fournier
Journal:  Biochem J       Date:  1998-01-15       Impact factor: 3.857

3.  Anionic subsites of the catalytic center of acetylcholinesterase from Torpedo and from cobra venom.

Authors:  H J Kreienkamp; C Weise; R Raba; A Aaviksaar; F Hucho
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

4.  Immunocytochemical localization of secretory acetylcholinesterase of the parasitic nematode Nippostrongylus brasiliensis.

Authors:  M Nakazawa; M Yamada; R Uchikawa; N Arizono
Journal:  Cell Tissue Res       Date:  1995-04       Impact factor: 5.249

5.  Anionic subsites of the acetylcholinesterase from Torpedo californica: affinity labelling with the cationic reagent N,N-dimethyl-2-phenyl-aziridinium.

Authors:  C Weise; H J Kreienkamp; R Raba; A Pedak; A Aaviksaar; F Hucho
Journal:  EMBO J       Date:  1990-12       Impact factor: 11.598
  5 in total

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