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Literature DB >> 3024971

The Ace locus of Drosophila melanogaster: structural gene for acetylcholinesterase with an unusual 5' leader.

Abstract

The Ace locus of Drosophila melanogaster has been mapped at the molecular level. cDNA clones from the locus have been isolated and their sequence determined, confirming that Ace forms the structural gene for acetylcholinesterase (AChE). The cDNAs have a 1950 nucleotide open reading frame from which the complete amino acid sequence of AChE has been deduced. The Drosophila enzyme is found to have extensive homology to the known sequence of Torpedo AChE. Ace cDNAs have an unusual structure with a long 5' leader and several short upstream open reading frames.

Entities: Chemical

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Year: 1986 PMID： 3024971 PMCID： PMC1167246 DOI： 10.1002/j.1460-2075.1986.tb04591.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

48 in total

1. Physicochemical behaviour and structural characteristics of membrane-bound acetylcholinesterase from Torpedo electric organ. Effect of phosphatidylinositol-specific phospholipase C.

Authors: A H Futerman; R M Fiorini; E Roth; M G Low; I Silman
Journal: Biochem J Date: 1985-03-01 Impact factor: 3.857

Review 2. Genetic analysis of Drosophila neurobiology.

Authors: J C Hall; R J Greenspan
Journal: Annu Rev Genet Date: 1979 Impact factor: 16.830

3. Multiple upstream AUG codons mediate translational control of GCN4.

Authors: P P Mueller; A G Hinnebusch
Journal: Cell Date: 1986-04-25 Impact factor: 41.582

4. Antigenic and structural differences in the catalytic subunits of the molecular forms of acetylcholinesterase.

Authors: B P Doctor; S Camp; M K Gentry; S S Taylor; P Taylor
Journal: Proc Natl Acad Sci U S A Date: 1983-09 Impact factor: 11.205

5. Nucleotide sequences of heat shock activated genes in Drosophila melanogaster. I. Sequences in the regions of the 5' and 3' ends of the hsp 70 gene in the hybrid plasmid 56H8.

Authors: I Török; F Karch
Journal: Nucleic Acids Res Date: 1980-07-25 Impact factor: 16.971

6. A simple method for displaying the hydropathic character of a protein.

Authors: J Kyte; R F Doolittle
Journal: J Mol Biol Date: 1982-05-05 Impact factor: 5.469

7. Method to determine the reading frame of a protein from the purine/pyrimidine genome sequence and its possible evolutionary justification.

Authors: J C Shepherd
Journal: Proc Natl Acad Sci U S A Date: 1981-03 Impact factor: 11.205

8. Recognition of protein coding regions in DNA sequences.

Authors: J W Fickett
Journal: Nucleic Acids Res Date: 1982-09-11 Impact factor: 16.971

9. Acetylcholinesterase mutants in Drosophila and their effects on the structure and function of the central nervous system.

Authors: R J Greenspan; J A Finn; J C Hall
Journal: J Comp Neurol Date: 1980-02-15 Impact factor: 3.215

10. Transcripts, genes and bands in 315,000 base-pairs of Drosophila DNA.

Authors: L M Hall; P J Mason; P Spierer
Journal: J Mol Biol Date: 1983-09-05 Impact factor: 5.469

58 in total

Review 1. Comparison of butyrylcholinesterase and acetylcholinesterase.

Authors: A Chatonnet; O Lockridge
Journal: Biochem J Date: 1989-06-15 Impact factor: 3.857

2. Molecular and recombinational mapping of mutations in the Ace locus of Drosophila melanogaster.

Authors: R N Nagoshi; W M Gelbart
Journal: Genetics Date: 1987-11 Impact factor: 4.562

3. Genetics of the hemolymph esterases of Lucilia cuprina (Diptera: Calliphoridae).

Authors: J Lai-Fook; P H Smith
Journal: Biochem Genet Date: 1992-04 Impact factor: 1.890

4. Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure.

Authors: H Soreq; R Ben-Aziz; C A Prody; S Seidman; A Gnatt; L Neville; J Lieman-Hurwitz; E Lev-Lehman; D Ginzberg; Y Lipidot-Lifson
Journal: Proc Natl Acad Sci U S A Date: 1990-12 Impact factor: 11.205

5. Amphiphilic, glycophosphatidylinositol-specific phospholipase C (PI-PLC)-insensitive monomers and dimers of acetylcholinesterase.

Authors: S Bon; T L Rosenberry; J Massoulié
Journal: Cell Mol Neurobiol Date: 1991-02 Impact factor: 5.046

6. Cholinesterases in cellular and molecular neurobiology.

Authors:
Journal: Cell Mol Neurobiol Date: 1991-02 Impact factor: 5.046

7. Characterization and functional expression in mammalian cells of genomic and cDNA clones encoding a Drosophila muscarinic acetylcholine receptor.

Authors: R A Shapiro; B T Wakimoto; E M Subers; N M Nathanson
Journal: Proc Natl Acad Sci U S A Date: 1989-11 Impact factor: 11.205

8. Solubilization, molecular forms, purification and substrate specificity of two acetylcholinesterases in the medicinal leech (Hirudo medicinalis).

Authors: V Talesa; M Grauso; E Giovannini; G Rosi; J P Toutant
Journal: Biochem J Date: 1995-03-15 Impact factor: 3.857

9. Recombinant human acetylcholinesterase is secreted from transiently transfected 293 cells as a soluble globular enzyme.

Authors: B Velan; C Kronman; H Grosfeld; M Leitner; Y Gozes; Y Flashner; T Sery; S Cohen; R Ben-Aziz; S Seidman
Journal: Cell Mol Neurobiol Date: 1991-02 Impact factor: 5.046

10. Recombinant expression and biochemical characterization of the catalytic domain of acetylcholinesterase-1 from the African malaria mosquito, Anopheles gambiae.

Authors: Haobo Jiang; Siwei Liu; Picheng Zhao; Carey Pope
Journal: Insect Biochem Mol Biol Date: 2009-07-14 Impact factor: 4.714