Literature DB >> 2339676

Protection against Amanita phalloides by the iridoid glycoside mixture of Picrorhiza kurroa (kutkin).

G L Floersheim1, A Bieri, R Koenig, A Pletscher.   

Abstract

Survival of mice after lethal doses of lyophilizate from Amanita phalloides ('death cap') was markedly increased by pretreatment with single doses of kutkin, a mixture of iridoid glycosides picroside I and kutkoside isolated from the roots of Picrorhiza kurroa. The protective effect of kutkin was comparable to that of silibinin. The curative efficacy of kutkin appeared to be slightly superior.

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Year:  1990        PMID： 2339676     DOI： 10.1007/bf01966472

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  8 in total

1.  Hepatoprotective activity of kutkin--the iridoid glycoside mixture of Picrorhiza kurrooa.

Authors:  R A Ansari; B S Aswal; R Chander; B N Dhawan; N K Garg; N K Kapoor; D K Kulshreshtha; H Mehdi; B N Mehrotra; G K Patnaik
Journal:  Indian J Med Res       Date:  1988-04       Impact factor: 2.375

Review 2.  Treatment of human amatoxin mushroom poisoning. Myths and advances in therapy.

Authors:  G L Floersheim
Journal:  Med Toxicol       Date:  1987 Jan-Feb

3.  Effects of penicillin and silymarin on liver enzymes and blood clotting factors in dogs given a boiled preparation of Amanita phalloides.

Authors:  G L Floersheim; M Eberhard; P Tschumi; F Duckert
Journal:  Toxicol Appl Pharmacol       Date:  1978-11       Impact factor: 4.219

4.  [Therapy of Amanita phalloides poisoning].

Authors:  G L Floersheim
Journal:  Dtsch Med Wochenschr       Date:  1983-06-03       Impact factor: 0.628

5.  Influence of zinc, D-penicillamine and oxygen on poisoning with Amanita phalloides. Zinc accelerates liver regeneration and prevents the depletion of brain noradrenaline caused by the mushroom.

Authors:  G L Floersheim; L Bianchi; A Probst; N Chiodetti; C G Honegger
Journal:  Agents Actions       Date:  1984-01

6.  [Clinical death-cap (Amanita phalloides) poisoning: prognostic factors and therapeutic measures. Analysis of 205 cases].

Authors:  G L Floersheim; O Weber; P Tschumi; M Ulbrich
Journal:  Schweiz Med Wochenschr       Date:  1982-08-21

7.  Chemotherapy of Amanita phalloides poisoning with intravenous silibinin.

Authors:  K Hruby; G Csomos; M Fuhrmann; H Thaler
Journal:  Hum Toxicol       Date:  1983-04

8.  Protection against acute ethanol toxicity in mice by zinc aspartate, glycols, levulose and pyritinol.

Authors:  G L Floersheim
Journal:  Agents Actions       Date:  1985-09
  8 in total
  3 in total

1.  Effect of altitude on picroside content in core collections of Picrorhiza kurrooa from the north western Himalayas.

Authors:  Meenu Katoch; I S Fazli; K A Suri; A Ahuja; G N Qazi
Journal:  J Nat Med       Date:  2011-02-24       Impact factor: 2.343

2.  Light and temperature regulated terpene biosynthesis: hepatoprotective monoterpene picroside accumulation in Picrorhiza kurrooa.

Authors:  Tabasum Kawoosa; Harsharan Singh; Amit Kumar; Sunil Kumar Sharma; Kiran Devi; Som Dutt; Surender Kumar Vats; Madhu Sharma; Paramvir Singh Ahuja; Sanjay Kumar
Journal:  Funct Integr Genomics       Date:  2010-01-14       Impact factor: 3.410

3.  A Complex Multiherbal Regimen Based on Ayurveda Medicine for the Management of Hepatic Cirrhosis Complicated by Ascites: Nonrandomized, Uncontrolled, Single Group, Open-Label Observational Clinical Study.

Authors:  Manish V Patel; Kalapi B Patel; Shivenarain Gupta; Andreas Michalsen; Elmar Stapelfeldt; Christian S Kessler
Journal:  Evid Based Complement Alternat Med       Date:  2015-08-03       Impact factor: 2.629
  3 in total

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