Literature DB >> 6702510

Influence of zinc, D-penicillamine and oxygen on poisoning with Amanita phalloides. Zinc accelerates liver regeneration and prevents the depletion of brain noradrenaline caused by the mushroom.

G L Floersheim, L Bianchi, A Probst, N Chiodetti, C G Honegger.   

Abstract

Pretreatment with zinc aspartate increased the survival rate of mice poisoned with a lyophilisate from the mushroom Amanita phalloides (APL). In the livers of the zinc-treated animals, confluent necrosis was cleared earlier. Zinc also prevented the reduction of brain noradrenaline caused by the mushroom as well as the rise of brain dopamine and brain weight. D-Penicillamine also protected against the lethal effects of APL. The survival afforded by zinc pretreatment was marginally ameliorated by additional oxygenation.

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Year:  1984        PMID： 6702510     DOI： 10.1007/bf01966845

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  12 in total

1.  Treatment of experimental poisoning produced by extracts of Amanita phalloides.

Authors:  G L Floersheim
Journal:  Toxicol Appl Pharmacol       Date:  1975-12       Impact factor: 4.219

Review 2.  [Experimental basis for the therapy of Amanita phalloides poisoning].

Authors:  G L Floersheim
Journal:  Schweiz Med Wochenschr       Date:  1978-02-11

3.  Enzyme histochemical investigations of the inhibitory effect of zinc on the injurious action of carbon tetrachloride on the liver.

Authors:  T Saldeen; U Brunk
Journal:  Frankf Z Pathol       Date:  1967

4.  Correlation of behavioural differences in three strains of mice with differences in brain amines.

Authors:  E Kempf; J Greilsamer; G Mack; P Mandel
Journal:  Nature       Date:  1974-02-15       Impact factor: 49.962

Review 5.  Poisonous principles of mushrooms of the genus Amanita. Four-carbon amines acting on the central nervous system and cell-destroying cyclic peptides are produced.

Authors:  T Wieland
Journal:  Science       Date:  1968-03-01       Impact factor: 47.728

6.  Antagonistic effects to phalloidin, alpha-amanitin and extracts of Amanita phalloides.

Authors:  G L Floersheim
Journal:  Agents Actions       Date:  1971-11

7.  Hepatic drug metabolism in zinc-deficient rats.

Authors:  G C Becking; A B Morrison
Journal:  Biochem Pharmacol       Date:  1970-03       Impact factor: 5.858

8.  Effects of penicillin and silymarin on liver enzymes and blood clotting factors in dogs given a boiled preparation of Amanita phalloides.

Authors:  G L Floersheim; M Eberhard; P Tschumi; F Duckert
Journal:  Toxicol Appl Pharmacol       Date:  1978-11       Impact factor: 4.219

9.  Characterization of the isolated perfused mouse brain as a system for neurochemical studies.

Authors:  J F Towell; V G Erwin
Journal:  Brain Res       Date:  1981-03-30       Impact factor: 3.252

10.  Determination of dopa, dopamine, dopac, epinephrine, norepinephrine, alpha-monofluoromethyldopa and alpha-difluoromethyldopa in various tissues of mice and rats using reversed-phase ion-pair liquid chromatography with electrochemical detection.

Authors:  J Wagner; M Palfreyman; M Zraika
Journal:  J Chromatogr       Date:  1979-09-11
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  4 in total

Review 1.  Treatment of human amatoxin mushroom poisoning. Myths and advances in therapy.

Authors:  G L Floersheim
Journal:  Med Toxicol       Date:  1987 Jan-Feb

2.  Protection against Amanita phalloides by the iridoid glycoside mixture of Picrorhiza kurroa (kutkin).

Authors:  G L Floersheim; A Bieri; R Koenig; A Pletscher
Journal:  Agents Actions       Date:  1990-03

3.  Synergism of organic zinc salts and sulfhydryl compounds (thiols) in the protection of mice against acute ethanol toxicity, and protective effects of various metal salts.

Authors:  G L Floersheim
Journal:  Agents Actions       Date:  1987-06

4.  Protection against acute ethanol toxicity in mice by zinc aspartate, glycols, levulose and pyritinol.

Authors:  G L Floersheim
Journal:  Agents Actions       Date:  1985-09
  4 in total

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