Literature DB >> 23792341

Obesity leads to higher risk of sperm DNA damage in infertile patients.

Charlotte Dupont1, Céline Faure, Nathalie Sermondade, Marouane Boubaya, Florence Eustache, Patrice Clément, Pascal Briot, Isabelle Berthaut, Vincent Levy, Isabelle Cedrin-Durnerin, Brigitte Benzacken, Pascale Chavatte-Palmer, Rachel Levy.   

Abstract

There has been a growing interest over the past few years in the impact of male nutrition on fertility. Infertility has been linked to male overweight or obesity, and conventional semen parameter values seem to be altered in case of high body mass index (BMI). A few studies assessing the impact of BMI on sperm DNA integrity have been published, but they did not lead to a strong consensus. Our objective was to explore further the relationship between sperm DNA integrity and BMI, through a 3-year multicentre study. Three hundred and thirty male partners in subfertile couples were included. Using the terminal uridine nick-end labelling (TUNEL) assay, we observed an increased rate of sperm DNA damage in obese men (odds ratio (95% confidence interval): 2.5 (1.2-5.1)).

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Year:  2013        PMID： 23792341      PMCID： PMC3881654          DOI： 10.1038/aja.2013.65

Source DB:  PubMed          Journal:  Asian J Androl        ISSN： 1008-682X            Impact factor:   3.285


  23 in total

1.  Negative effect of increased body weight on sperm conventional and nonconventional flow cytometric sperm parameters.

Authors:  Sandro La Vignera; Rosita A Condorelli; Enzo Vicari; Aldo E Calogero
Journal:  J Androl       Date:  2011-01-27

2.  Association between obesity and alteration of sperm DNA integrity and mitochondrial activity.

Authors:  Roberta M Fariello; Juliana R Pariz; Deborah M Spaine; Agnaldo P Cedenho; Ricardo P Bertolla; Renato Fraietta
Journal:  BJU Int       Date:  2012-02-02       Impact factor: 5.588

Review 3.  Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis.

Authors:  Denny Sakkas; Juan G Alvarez
Journal:  Fertil Steril       Date:  2010-01-18       Impact factor: 7.329

4.  You are what your dad ate.

Authors:  Anne C Ferguson-Smith; Mary-Elizabeth Patti
Journal:  Cell Metab       Date:  2011-02-02       Impact factor: 27.287

5.  Impact of body mass index on seminal oxidative stress.

Authors:  O Tunc; H W Bakos; K Tremellen
Journal:  Andrologia       Date:  2010-12-29       Impact factor: 2.775

6.  The BMI of men and not sperm parameters impact on embryo quality and the IVF outcome.

Authors:  G Anifandis; K Dafopoulos; C I Messini; N Polyzos; I E Messinis
Journal:  Andrology       Date:  2012-09-16       Impact factor: 3.842

7.  Men's body mass index in relation to embryo quality and clinical outcomes in couples undergoing in vitro fertilization.

Authors:  Daniela S Colaci; Myriam Afeiche; Audrey J Gaskins; Diane L Wright; Thomas L Toth; Cigdem Tanrikut; Russ Hauser; Jorge E Chavarro
Journal:  Fertil Steril       Date:  2012-08-09       Impact factor: 7.329

8.  Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic.

Authors:  Jorge E Chavarro; Thomas L Toth; Diane L Wright; John D Meeker; Russ Hauser
Journal:  Fertil Steril       Date:  2009-03-03       Impact factor: 7.329

9.  The influence of female and male body mass index on live births after assisted reproductive technology treatment: a nationwide register-based cohort study.

Authors:  Gitte Lindved Petersen; Lone Schmidt; Anja Pinborg; Mads Kamper-Jørgensen
Journal:  Fertil Steril       Date:  2013-02-05       Impact factor: 7.329

10.  Extent of nuclear DNA damage in ejaculated spermatozoa impacts on blastocyst development after in vitro fertilization.

Authors:  Emre Seli; David K Gardner; William B Schoolcraft; Odette Moffatt; Denny Sakkas
Journal:  Fertil Steril       Date:  2004-08       Impact factor: 7.329
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  49 in total

Review 1.  How much does obesity affect the male reproductive function?

Authors:  Giuseppe Bellastella; Davide Menafra; Giulia Puliani; Annamaria Colao; Silvia Savastano
Journal:  Int J Obes Suppl       Date:  2019-04-12

2.  Removal of DNA-fragmented spermatozoa using flow cytometry and sorting does not improve the outcome of intracytoplasmic sperm injection.

Authors:  Christian De Geyter; Ursula Gobrecht-Keller; Astrid Ahler; Manuel Fischer
Journal:  J Assist Reprod Genet       Date:  2019-08-28       Impact factor: 3.412

3.  Protective effects of metformin on reproductive function in obese male rats induced by high-fat diet.

Authors:  Wen-jie Yan; Yang Mu; Nan Yu; Tai-lang Yi; Yi Zhang; Xiang-li Pang; Dan Cheng; Jing Yang
Journal:  J Assist Reprod Genet       Date:  2015-06-17       Impact factor: 3.412

Review 4.  Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health.

Authors:  Undraga Schagdarsurengin; Klaus Steger
Journal:  Nat Rev Urol       Date:  2016-08-31       Impact factor: 14.432

5.  Sperm DNA damage-the effect of stress and everyday life factors.

Authors:  M Radwan; J Jurewicz; D Merecz-Kot; W Sobala; P Radwan; M Bochenek; W Hanke
Journal:  Int J Impot Res       Date:  2016-04-14       Impact factor: 2.896

6.  A decrease of docosahexaenoic acid in testes of mice fed a high-fat diet is associated with impaired sperm acrosome reaction and fertility.

Authors:  Julio Bunay; Luz-Maria Gallardo; Jorge Luis Torres-Fuentes; M Verónica Aguirre-Arias; Renan Orellana; Néstor Sepúlveda; Ricardo D Moreno
Journal:  Asian J Androl       Date:  2021 May-Jun       Impact factor: 3.285

Review 7.  Male obesity and subfertility, is it really about increased adiposity?

Authors:  Nicole O McPherson; Michelle Lane
Journal:  Asian J Androl       Date:  2015 May-Jun       Impact factor: 3.285

8.  Body Mass Index Is Associated with Impaired Semen Characteristics and Reduced Levels of Anti-Müllerian Hormone across a Wide Weight Range.

Authors:  Jorunn M Andersen; Hilde Herning; Elin L Aschim; Jøran Hjelmesæth; Tom Mala; Hans Ivar Hanevik; Mona Bungum; Trine B Haugen; Oliwia Witczak
Journal:  PLoS One       Date:  2015-06-12       Impact factor: 3.240

9.  Moderate calorie restriction ameliorates reproduction via attenuating oxidative stress-induced apoptosis through SIRT1 signaling in obese mice.

Authors:  Shaohong Zhang; Mengxiao Zhang; Shuoshuo Sun; Xiao Wei; Yu Chen; Peng Zhou; Rendong Zheng; Guofang Chen; Chao Liu
Journal:  Ann Transl Med       Date:  2021-06

Review 10.  Functions and Mechanisms of Lysine Glutarylation in Eukaryotes.

Authors:  Longxiang Xie; Yafei Xiao; Fucheng Meng; Yongqiang Li; Zhenyu Shi; Keli Qian
Journal:  Front Cell Dev Biol       Date:  2021-06-24
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