| Literature DB >> 23392846 |
Huailei Liu1, Dayong Han, Yaohua Liu, Xu Hou, Jianing Wu, Huadong Li, Jie Yang, Chen Shen, Guang Yang, Changyu Fu, Xianfeng Li, Hui Che, Jing Ai, Shiguang Zhao.
Abstract
Harmine hydrochloride (Har-hc), a derivative from Harmine which is a natural extractive from plants, has been considered for treatment of kinds of cancers and cerebral diseases. In this study, we found that Har-hc clearly decreased cell viability, induced apoptosis and inhibited Akt phosphorylation in glioblastoma cell lines. Moreover, Har-hc had the ability to inhibit self-renewal and promote differentiation of glioblastoma stem like cells (GSLCs) accompanied by inhibition of Akt phosphorylation. Especially, we demonstrated that Har-hc inhibited neurosphere formation of human primary GSLCs. In vivo test also confirmed Har-hc decreased the tumorigenicity of GSLCs. Thus we conclude that Har-hc has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation. Administration of Har-hc may act as a new approach to glioblastoma treatment.Entities:
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Year: 2013 PMID： 23392846 DOI： 10.1007/s11060-012-1034-x
Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130