Literature DB >> 26899500

Cancer stem cells and chemoresistance: The smartest survives the raid.

Jihe Zhao1.   

Abstract

Chemoresistant metastatic relapse of minimal residual disease plays a significant role for poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell (CSC) behind the mechanisms for this deadly disease. This review briefly introduces the basics of the conventional chemotherapies, updates the CSC theories, highlights the molecular and cellular mechanisms by which CSC smartly designs and utilizes multiple lines of self-defense to avoid being killed by chemotherapy, and concisely summarizes recent progress in studies on CSC-targeted therapies in the end, with the hope to help guide future research toward developing more effective therapeutic strategies to eradicate tumor cells in the patients.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cancer stem cell; Chemoresistance; Chemotherapy; Targeted therapy

Mesh：

Substances：

Year:  2016        PMID： 26899500      PMCID： PMC4808328          DOI： 10.1016/j.pharmthera.2016.02.008

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  304 in total

1.  Modeling pO(2) distributions in the bone marrow hematopoietic compartment. I. Krogh's model.

Authors:  D C Chow; L A Wenning; W M Miller; E T Papoutsakis
Journal:  Biophys J       Date:  2001-08       Impact factor: 4.033

Review 2.  Cancer stem cells: mirage or reality?

Authors:  Piyush B Gupta; Christine L Chaffer; Robert A Weinberg
Journal:  Nat Med       Date:  2009-09-04       Impact factor: 53.440

3.  Celecoxib downregulates CD133 expression through inhibition of the Wnt signaling pathway in colon cancer cells.

Authors:  Yanhong Deng; Qiao Su; Jianwen Mo; Xinhui Fu; Yan Zhang; Edward H Lin
Journal:  Cancer Invest       Date:  2012-12-17       Impact factor: 2.176

Review 4.  Stem cells of the skin epithelium.

Authors:  Laura Alonso; Elaine Fuchs
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-11       Impact factor: 11.205

Review 5.  Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance.

Authors:  Bryan P Toole; Mark G Slomiany
Journal:  Drug Resist Updat       Date:  2008-05-19       Impact factor: 18.500

6.  Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells.

Authors:  Yiwei Li; Timothy G VandenBoom; Dejuan Kong; Zhiwei Wang; Shadan Ali; Philip A Philip; Fazlul H Sarkar
Journal:  Cancer Res       Date:  2009-08-04       Impact factor: 12.701

Review 7.  Targeting multidrug resistance in cancer.

Authors:  Gergely Szakács; Jill K Paterson; Joseph A Ludwig; Catherine Booth-Genthe; Michael M Gottesman
Journal:  Nat Rev Drug Discov       Date:  2006-03       Impact factor: 84.694

Review 8.  Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers.

Authors:  Michèle Sabbah; Shahin Emami; Gérard Redeuilh; Sylvia Julien; Grégoire Prévost; Amazia Zimber; Radia Ouelaa; Marc Bracke; Olivier De Wever; Christian Gespach
Journal:  Drug Resist Updat       Date:  2008-08-20       Impact factor: 18.500

9.  Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.

Authors:  Arnout G Schepers; Hugo J Snippert; Daniel E Stange; Maaike van den Born; Johan H van Es; Marc van de Wetering; Hans Clevers
Journal:  Science       Date:  2012-08-01       Impact factor: 47.728

10.  Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung carcinoma.

Authors:  Barbara A Frederick; Barbara A Helfrich; Christopher D Coldren; Di Zheng; Dan Chan; Paul A Bunn; David Raben
Journal:  Mol Cancer Ther       Date:  2007-05-31       Impact factor: 6.261
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  141 in total

1.  Three-Dimensional Cellular Arrangement in Epithelial Ovarian Cancer Cell Lines TOV-21G and SKOV-3 is Associated with Apoptosis-Related miRNA Expression Modulation.

Authors:  Aline Brito de Lima; Luciana Maria Silva; Nikole Gontijo Gonçales; Maria Raquel Santos Carvalho; Agnaldo Lopes da Silva Filho; Letícia da Conceição Braga
Journal:  Cancer Microenviron       Date:  2018-01-06

2.  Cancer Cell Plasticity: Rapid Reversal of Chemosensitivity and Expression of Stemness Markers in Lung and Breast Cancer Tumorspheres.

Authors:  Juan Sebastian Yakisich; Neelam Azad; Vivek Kaushik; Anand Krishnan V Iyer
Journal:  J Cell Physiol       Date:  2017-03-31       Impact factor: 6.384

3.  Beta-hairpin hydrogels as scaffolds for high-throughput drug discovery in three-dimensional cell culture.

Authors:  Peter Worthington; Katherine M Drake; Zhiqin Li; Andrew D Napper; Darrin J Pochan; Sigrid A Langhans
Journal:  Anal Biochem       Date:  2017-07-27       Impact factor: 3.365

4.  Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden.

Authors:  David C Montrose; Xi Kathy Zhou; Erin M McNally; Erika Sue; Rhonda K Yantiss; Steven S Gross; Nitai D Leve; Edward D Karoly; Chen S Suen; Lilan Ling; Robert Benezra; Eric G Pamer; Andrew J Dannenberg
Journal:  Cancer Prev Res (Phila)       Date:  2016-07-18

5.  Monepantel considerably enhances the therapeutic potentials of PEGylated liposomal doxorubicin and gemcitabine in ovarian cancer: in vitro and in vivo studies.

Authors:  Parvin Ataie-Kachoie; Krishna Pillai; Samina Badar; Javed Akhter; David Lawson Morris
Journal:  Am J Cancer Res       Date:  2018-10-01       Impact factor: 6.166

6.  Repurposing itraconazole as an anticancer agent.

Authors:  Hiroshi Tsubamoto; Tomoko Ueda; Kayo Inoue; Kazuko Sakata; Hiroaki Shibahara; Takashi Sonoda
Journal:  Oncol Lett       Date:  2017-06-07       Impact factor: 2.967

Review 7.  p53 and Cell Fate: Sensitizing Head and Neck Cancer Stem Cells to Chemotherapy.

Authors:  Christie Rodriguez-Ramirez; Jacques E Nör
Journal:  Crit Rev Oncog       Date:  2018

8.  Optimizing Targeted Inhibitors of P-Glycoprotein Using Computational and Structure-Guided Approaches.

Authors:  John G Wise; Amila K Nanayakkara; Maha Aljowni; Gang Chen; Maisa C De Oliveira; Lauren Ammerman; Ketetha Olengue; Alexander R Lippert; Pia D Vogel
Journal:  J Med Chem       Date:  2019-11-26       Impact factor: 7.446

9.  Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis.

Authors:  Trayambak Pathak; Maxime Gueguinou; Vonn Walter; Celine Delierneux; Martin T Johnson; Xuexin Zhang; Ping Xin; Ryan E Yoast; Scott M Emrich; Gregory S Yochum; Israel Sekler; Walter A Koltun; Donald L Gill; Nadine Hempel; Mohamed Trebak
Journal:  Elife       Date:  2020-09-11       Impact factor: 8.140

Review 10.  Overcoming chemoresistance by targeting reprogrammed metabolism: the Achilles' heel of pancreatic ductal adenocarcinoma.

Authors:  Abudureyimu Tuerhong; Jin Xu; Si Shi; Zhen Tan; Qingcai Meng; Jie Hua; Jiang Liu; Bo Zhang; Wei Wang; Xianjun Yu; Chen Liang
Journal:  Cell Mol Life Sci       Date:  2021-06-15       Impact factor: 9.261
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