Literature DB >> 23391068

Incomplete knowledge of the clinical context as a barrier to interpreting incidental genetic research findings.

Gregory Costain1, Anne S Bassett.   

Abstract

Mesh：

Year:  2013        PMID： 23391068      PMCID： PMC4459859          DOI： 10.1080/15265161.2012.754063

Source DB:  PubMed          Journal:  Am J Bioeth        ISSN： 1526-5161            Impact factor:   11.229


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  10 in total

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4.  The ever-evolving concept of clinical significance and the potential for sins of omission in genetic research.

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5.  Offering individual genetic research results: context matters.

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6.  Secondary variants in individuals undergoing exome sequencing: screening of 572 individuals identifies high-penetrance mutations in cancer-susceptibility genes.

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8.  Do researchers have an obligation to actively look for genetic incidental findings?

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9.  Incidental medical information in whole-exome sequencing.

Authors:  Benjamin D Solomon; Donald W Hadley; Daniel E Pineda-Alvarez; Aparna Kamat; Jamie K Teer; Praveen F Cherukuri; Nancy F Hansen; Pedro Cruz; Alice C Young; Benjamin E Berkman; Settara C Chandrasekharappa; James C Mullikin
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10.  Update and analysis of the University College London low density lipoprotein receptor familial hypercholesterolemia database.

Authors:  S E A Leigh; A H Foster; R A Whittall; C S Hubbart; S E Humphries
Journal:  Ann Hum Genet       Date:  2008-03-05       Impact factor: 1.670
  10 in total
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1.  Canadian Research Ethics Board Leadership Attitudes to the Return of Genetic Research Results to Individuals and Their Families.

Authors:  Conrad V Fernandez; P Pearl O'Rourke; Laura M Beskow
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2.  Response to open peer commentaries on "do researchers have an obligation to actively look for genetic incidental findings?".

Authors:  Catherine Gliwa; Benjamin E Berkman
Journal:  Am J Bioeth       Date:  2013       Impact factor: 11.229

3.  Attitudes of genetics professionals toward the return of incidental results from exome and whole-genome sequencing.

Authors:  Joon-Ho Yu; Tanya M Harrell; Seema M Jamal; Holly K Tabor; Michael J Bamshad
Journal:  Am J Hum Genet       Date:  2014-06-26       Impact factor: 11.025

Review 4.  The Human Genome Project, and recent advances in personalized genomics.

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Journal:  Risk Manag Healthc Policy       Date:  2015-02-16

5.  Incidental findings of uncertain significance: To know or not to know--that is not the question.

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6.  ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.

Authors:  Robert C Green; Jonathan S Berg; Wayne W Grody; Sarah S Kalia; Bruce R Korf; Christa L Martin; Amy L McGuire; Robert L Nussbaum; Julianne M O'Daniel; Kelly E Ormond; Heidi L Rehm; Michael S Watson; Marc S Williams; Leslie G Biesecker
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  6 in total

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