Literature DB >> 10784452

Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22.

L M Brzustowicz1, K A Hodgkinson, E W Chow, W G Honer, A S Bassett.   

Abstract

Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings. A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to allow the positional cloning of the underlying susceptibility gene.

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Year:  2000        PMID： 10784452      PMCID： PMC3787922          DOI： 10.1126/science.288.5466.678

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  35 in total

1.  Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases.

Authors:  P C Abreu; D A Greenberg; S E Hodge
Journal:  Am J Hum Genet       Date:  1999-09       Impact factor: 11.025

2.  Autosome search for schizophrenia susceptibility genes in multiply affected families.

Authors:  M I Rees; I Fenton; N M Williams; P Holmans; N Norton; A Cardno; P Asherson; G Spurlock; E Roberts; E Parfitt; R Mant; H Vallada; E Dawson; M W Li; D A Collier; J F Powell; S Nanko; M Gill; P McGuffin; M J Owen
Journal:  Mol Psychiatry       Date:  1999-07       Impact factor: 15.992

3.  Linkage strategies for genetically complex traits. I. Multilocus models.

Authors:  N Risch
Journal:  Am J Hum Genet       Date:  1990-02       Impact factor: 11.025

4.  Further evidence for the increased power of LOD scores compared with nonparametric methods.

Authors:  M Durner; V J Vieland; D A Greenberg
Journal:  Am J Hum Genet       Date:  1999-01       Impact factor: 11.025

5.  hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21.

Authors:  V Dror; E Shamir; S Ghanshani; R Kimhi; M Swartz; Y Barak; R Weizman; L Avivi; T Litmanovitch; E Fantino; K Kalman; E G Jones; K G Chandy; J J Gargus; G A Gutman; R Navon
Journal:  Mol Psychiatry       Date:  1999-05       Impact factor: 15.992

6.  Linkage of familial schizophrenia to chromosome 13q32.

Authors:  L M Brzustowicz; W G Honer; E W Chow; D Little; J Hogan; K Hodgkinson; A S Bassett
Journal:  Am J Hum Genet       Date:  1999-10       Impact factor: 11.025

7.  A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci.

Authors:  I Hovatta; T Varilo; J Suvisaari; J D Terwilliger; V Ollikainen; R Arajärvi; H Juvonen; M L Kokko-Sahin; L Väisänen; H Mannila; J Lönnqvist; L Peltonen
Journal:  Am J Hum Genet       Date:  1999-10       Impact factor: 11.025

8.  Computer-simulation methods in human linkage analysis.

Authors:  J Ott
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205

9.  A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2.

Authors:  S D Detera-Wadleigh; J A Badner; W H Berrettini; T Yoshikawa; L R Goldin; G Turner; D Y Rollins; T Moses; A R Sanders; J D Karkera; L E Esterling; J Zeng; T N Ferraro; J J Guroff; D Kazuba; M E Maxwell; J I Nurnberger; E S Gershon
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205

10.  A two-stage genome scan for schizophrenia susceptibility genes in 196 affected sibling pairs.

Authors:  N M Williams; M I Rees; P Holmans; N Norton; A G Cardno; L A Jones; K C Murphy; R D Sanders; G McCarthy; M Y Gray; I Fenton; P McGuffin; M J Owen
Journal:  Hum Mol Genet       Date:  1999-09       Impact factor: 6.150
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  114 in total

Review 1.  Genetic insights into schizophrenia.

Authors:  A S Bassett; E W Chow; D M Waterworth; L Brzustowicz
Journal:  Can J Psychiatry       Date:  2001-03       Impact factor: 4.356

2.  Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23.

Authors:  H M Gurling; G Kalsi; J Brynjolfson; T Sigmundsson; R Sherrington; B S Mankoo; T Read; P Murphy; E Blaveri; A McQuillin; H Petursson; D Curtis
Journal:  Am J Hum Genet       Date:  2001-03       Impact factor: 11.025

Review 3.  Genetics of schizophrenia and the new millennium: progress and pitfalls.

Authors:  M Baron
Journal:  Am J Hum Genet       Date:  2001-01-17       Impact factor: 11.025

4.  Schizophrenia: more dopamine, more D2 receptors.

Authors:  P Seeman; S Kapur
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-05       Impact factor: 11.205

5.  Patterns of dysmorphic features in schizophrenia.

Authors:  L E Scutt; E W Chow; R Weksberg; W G Honer; A S Bassett
Journal:  Am J Med Genet       Date:  2001-12-08

Review 6.  Recent advances in the genetics of schizophrenia.

Authors:  D M Waterwort; A S Bassett; L M Brzustowicz
Journal:  Cell Mol Life Sci       Date:  2002-02       Impact factor: 9.261

7.  A schizophrenia-susceptibility locus at 6q25, in one of the world's largest reported pedigrees.

Authors:  E Lindholm; B Ekholm; S Shaw; P Jalonen; G Johansson; U Pettersson; R Sherrington; R Adolfsson; E Jazin
Journal:  Am J Hum Genet       Date:  2001-05-25       Impact factor: 11.025

8.  Genomic anatomy of a premier major histocompatibility complex paralogous region on chromosome 1q21-q22.

Authors:  T Shiina; A Ando; Y Suto; F Kasai; A Shigenari; N Takishima; E Kikkawa; K Iwata; Y Kuwano; Y Kitamura; Y Matsuzawa; K Sano; M Nogami; H Kawata; S Li; Y Fukuzumi; M Yamazaki; H Tashiro; G Tamiya; A Kohda; K Okumura; T Ikemura; E Soeda; N Mizuki; M Kimura; S Bahram; H Inoko
Journal:  Genome Res       Date:  2001-05       Impact factor: 9.043

9.  Genomewide multipoint linkage analysis of seven extended Palauan pedigrees with schizophrenia, by a Markov-chain Monte Carlo method.

Authors:  N J Camp; S L Neuhausen; J Tiobech; A Polloi; H Coon; M Myles-Worsley
Journal:  Am J Hum Genet       Date:  2001-10-19       Impact factor: 11.025

Review 10.  Linkage and association studies of schizophrenia.

Authors:  Peter McGuffin; Kopal Tandon; Alejandro Corsico
Journal:  Curr Psychiatry Rep       Date:  2003-06       Impact factor: 5.285
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