BACKGROUND: Non-motor symptoms (NMS) in Parkinson's disease (PD) are frequent, increase the patients' disability and have an important negative impact on their quality of life. METHODS: We used a Dutch translation of the Non-Motor Symptoms Questionnaire (NMSQuest) to identify NMS in a population of 215 Belgian PD patients. RESULTS: A median number of 8 NMS was reported per patient. Urinary urgency (59.2 %), nocturia (56.9 %), insomnia (45.8 %), attention problems (45.5 %) and orthostatism (41.2 %) were the most frequently denoted NMS. A higher number of NMS was present with more severe Hoehn and Yahr stages. Longer disease duration was associated with more NMS. Furthermore, clinical markers of disease progression were also associated with a higher number of NMS. However, early-onset patients (< 50 years) reported less NMS than late-onset patients after correction for disease duration. Interestingly, in early-onset patients we observed more unexplained pain and more hyperhydrosis. CONCLUSION: We confirm the high prevalence of NMS in PD patients. A long disease duration and more severe disease are associated with a higher number of NMS. Importantly, even if late-onset patients generally report more NMS, unexplained pain and hyperhydrosis are more frequent in early-onset patients.
BACKGROUND: Non-motor symptoms (NMS) in Parkinson's disease (PD) are frequent, increase the patients' disability and have an important negative impact on their quality of life. METHODS: We used a Dutch translation of the Non-Motor Symptoms Questionnaire (NMSQuest) to identify NMS in a population of 215 Belgian PDpatients. RESULTS: A median number of 8 NMS was reported per patient. Urinary urgency (59.2 %), nocturia (56.9 %), insomnia (45.8 %), attention problems (45.5 %) and orthostatism (41.2 %) were the most frequently denoted NMS. A higher number of NMS was present with more severe Hoehn and Yahr stages. Longer disease duration was associated with more NMS. Furthermore, clinical markers of disease progression were also associated with a higher number of NMS. However, early-onset patients (< 50 years) reported less NMS than late-onset patients after correction for disease duration. Interestingly, in early-onset patients we observed more unexplained pain and more hyperhydrosis. CONCLUSION: We confirm the high prevalence of NMS in PDpatients. A long disease duration and more severe disease are associated with a higher number of NMS. Importantly, even if late-onset patients generally report more NMS, unexplained pain and hyperhydrosis are more frequent in early-onset patients.
Authors: Kallol Ray Chaudhuri; Pablo Martinez-Martin; Anthony H V Schapira; Fabrizio Stocchi; Kapil Sethi; Per Odin; Richard G Brown; William Koller; Paolo Barone; Graeme MacPhee; Linda Kelly; Martin Rabey; Doug MacMahon; Sue Thomas; William Ondo; David Rye; Alison Forbes; Susanne Tluk; Vandana Dhawan; Annette Bowron; Adrian J Williams; Charles W Olanow Journal: Mov Disord Date: 2006-07 Impact factor: 10.338
Authors: S Rios Romenets; C Wolfson; C Galatas; A Pelletier; R Altman; L Wadup; R B Postuma Journal: Parkinsonism Relat Disord Date: 2011-09-14 Impact factor: 4.891
Authors: M C de Rijk; L J Launer; K Berger; M M Breteler; J F Dartigues; M Baldereschi; L Fratiglioni; A Lobo; J Martinez-Lage; C Trenkwalder; A Hofman Journal: Neurology Date: 2000 Impact factor: 9.910
Authors: Pablo Martinez-Martin; Anthony H V Schapira; Fabrizio Stocchi; Kapil Sethi; Per Odin; Graeme MacPhee; Richard G Brown; Yogini Naidu; Lisa Clayton; Kazuo Abe; Yoshio Tsuboi; Dough MacMahon; Paolo Barone; Martin Rabey; Ubaldo Bonuccelli; Alison Forbes; Kieran Breen; Susanne Tluk; C Warren Olanow; Sue Thomas; David Rye; Annette Hand; Adrian J Williams; William Ondo; K Ray Chaudhuri Journal: Mov Disord Date: 2007-08-15 Impact factor: 10.338
Authors: Oluwadamilola O Ojo; Kolawole W Wahab; Abiodun H Bello; Sani A Abubakar; Bertha C Ekeh; Folajimi M Otubogun; Emmanuel U Iwuozo; Temitope H Farombi; Olaleye Adeniji; Francis I Ojini; Frank A Imarhiagbe; Yakub Nyandaiti; Morenikeji A Komolafe; Michael B Fawale; Gerald A Onwuegbuzie; Yusuf Zubair; Uduak E Williams; Funlola T Taiwo; Shyngle I Oyakhire; Olajumoke O Oshinaike; Nosakhare Osemwegie; Godwin O Osaigbovo; Francis E Odiase; Olanike A Odeniyi; Yahaya O Obiabo; Emmanuel E Obehighe; Ernest O Nwazor; Paul O Nwani; Abiodun J Kehinde; Cyril O Erameh; Oluchi S Ekenze; Franklin O Dike; Salisu A Balarabe; Ohwotemu Arigbodi; Babawale Arabambi; Ifeyinwa Ani-Osheku; Mohammed W Ali; John E Akpekpe; Rufus O Akinyemi; Uchechi Agulanna; Christian E Agu; Osigwe P Agabi; Babatunde A Ademiluyi; Akintunde A Adebowale; Charles O Achoru; Oladunni V Abiodun; Mie Rizig; Njideka U Okubadejo Journal: Mov Disord Clin Pract Date: 2021-10-06