Oluwadamilola O Ojo1,2, Kolawole W Wahab3, Abiodun H Bello4, Sani A Abubakar5, Bertha C Ekeh6, Folajimi M Otubogun7, Emmanuel U Iwuozo8, Temitope H Farombi9, Olaleye Adeniji10, Francis I Ojini1,2, Frank A Imarhiagbe11, Yakub Nyandaiti12, Morenikeji A Komolafe13, Michael B Fawale13, Gerald A Onwuegbuzie14, Yusuf Zubair15, Uduak E Williams16, Funlola T Taiwo17, Shyngle I Oyakhire15, Olajumoke O Oshinaike18, Nosakhare Osemwegie19, Godwin O Osaigbovo20, Francis E Odiase11, Olanike A Odeniyi21, Yahaya O Obiabo22, Emmanuel E Obehighe23, Ernest O Nwazor24, Paul O Nwani25, Abiodun J Kehinde26, Cyril O Erameh27, Oluchi S Ekenze28, Franklin O Dike6, Salisu A Balarabe29, Ohwotemu Arigbodi30, Babawale Arabambi31, Ifeyinwa Ani-Osheku32, Mohammed W Ali33, John E Akpekpe34, Rufus O Akinyemi35, Uchechi Agulanna2, Christian E Agu36, Osigwe P Agabi2, Babatunde A Ademiluyi37, Akintunde A Adebowale13, Charles O Achoru20, Oladunni V Abiodun38, Mie Rizig39, Njideka U Okubadejo1,2. 1. Neurology Unit, Department of Medicine, Faculty of Clinical Sciences College of Medicine, University of Lagos Lagos Nigeria. 2. Neurology Unit, Department of Medicine Lagos University Teaching Hospital Lagos Nigeria. 3. Department of Medicine University of Ilorin/University of Ilorin Teaching Hospital Ilorin Nigeria. 4. University of Ilorin Teaching Hospital Ilorin Nigeria. 5. Department of Medicine Ahmadu Bello University/Ahmadu Bello University Teaching Hospital Zaria Nigeria. 6. University of Uyo Teaching Hospital/Ibom Specialist Hospital Uyo Nigeria. 7. Olabisi Onabanjo University Teaching Hospital Sagamu Nigeria. 8. Neurology Unit Benue State University/Benue State University Teaching Hospital Makurdi Nigeria. 9. Chief Tony Anenih Geriatrics Center, University College Hospital Ibadan, Oyo Nigeria. 10. Federal Medical Center Abeokuta Nigeria. 11. University of Benin/University of Benin Teaching Hospital Benin City Nigeria. 12. University of Maiduguri/University of Maiduguri Teaching Hospital Maiduguri Nigeria. 13. Neurology Unit, Department of Medicine Obafemi Awolowo University/Obafemi Awolowo University Teaching Hospitals Complex Ile-Ife Nigeria. 14. University of Abuja Teaching Hospital Abuja Nigeria. 15. Department of Internal Medicine National Hospital Abuja Nigeria. 16. Department of Internal Medicine University of Calabar/University of Calabar Teaching Hospital Calabar Nigeria. 17. Department of Medicine University College Hospital Ibadan Nigeria. 18. Neurology Unit, Department of Medicine, Faculty of Clinical Sciences Lagos State University College of Medicine Ikeja Nigeria. 19. University of Port Harcourt/University of Port Harcourt Teaching Hospital Port Harcourt Nigeria. 20. Jos University Teaching Hospital Jos Nigeria. 21. General Hospital Lagos Island Nigeria. 22. Department of Internal Medicine Delta State University/Delta State University Teaching Hospital Oghara Nigeria. 23. Federal Medical Center Keffi Nigeria. 24. Department of Medicine Madonna University College of Medical Sciences/Federal Medical Center Elele/Owerri Nigeria. 25. Nnamdi Azikiwe University/Nnamdi Azikiwe University Teaching Hospital Nnewi Nigeria. 26. Federal Medical Center, Jabi, Federal Capital Territory Abuja Nigeria. 27. Irrua Specialist Hospital Irrua Nigeria. 28. Neurology Unit, Department of Medicine, Faculty of Medical Sciences University of Nigeria/University of Nigeria Teaching Hospital Ituku Ozalla Nigeria. 29. Department of Medicine College of Health Sciences, Usmanu Danfodiyo University/Usmanu Danfodiyo University Teaching Hospital Sokoto Nigeria. 30. Department of Internal Medicine Delta State University Teaching Hospital Oghara Nigeria. 31. Lagos State University Teaching Hospital Ikeja Nigeria. 32. Asokoro District Hospital, Asokoro, Federal Capital Territory Abuja Nigeria. 33. Federal Teaching Hospital Gombe Nigeria. 34. Federal Medical Center Asaba Nigeria. 35. Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan Ibadan Nigeria. 36. Alex Ekwueme Federal Teaching Hospital Abakaliki Nigeria. 37. Federal Medical Center Lokoja Nigeria. 38. General Hospital Isolo Nigeria. 39. Department of Molecular Neuroscience University College London Institute of Neurology London United Kingdom.
Abstract
BACKGROUND: Data on non-motor symptoms (NMS) in black Africans with Parkinson's disease (PD) are sparse. OBJECTIVE: To describe the profile of NMS in the Nigeria PD Registry (NPDR) cohort and explore the relationship between NMS and PD motor phenotype. METHODS: We conducted a cross-sectional study of the frequency and burden of NMS, based on the non-motor symptoms scale (NMSS) and the Chaudhuri method respectively in our cohort. Baseline demographics, disease characteristics (Hoehn and Yahr stage, MDS-UPDRS total score and Part III motor score), motor phenotype (based on Stebbin et al's algorithm), and levodopa equivalent daily dose (LEDD) were documented. RESULTS: Data are presented for 825 PD whose mean age at study was 63.7 ± 10.1 years, female sex-221 [26.8%] while median PD duration was 36 months. PD phenotypes included tremor-dominant 466 (56.5%), postural instability and gait disorder (PIGD) 259 (31.4%), and indeterminate 100 (12.1%). 82.6% were on treatment (median LEDD of 500 mg/24 hours). 804 (97.5%) endorsed at least 1 NMS. The median NMSS score was 26.0 while subscores for urinary and sexual function domains were significantly higher in males (P < 0.05). PIGD-PD had more frequent NMS and higher frequency of severe/very severe NMSS burden (P = 0.000 for both). Nocturia and fatigue were the most prevalent NMS overall and across motor subtypes. PIGD phenotype and total UPDRS scores were the independent determinants of NMSS scores (P = 0.000). CONCLUSION: The profile and burden of NMS, and association with motor subtype in our black African cohort is largely similar to descriptions from other populations.
BACKGROUND: Data on non-motor symptoms (NMS) in black Africans with Parkinson's disease (PD) are sparse. OBJECTIVE: To describe the profile of NMS in the Nigeria PD Registry (NPDR) cohort and explore the relationship between NMS and PD motor phenotype. METHODS: We conducted a cross-sectional study of the frequency and burden of NMS, based on the non-motor symptoms scale (NMSS) and the Chaudhuri method respectively in our cohort. Baseline demographics, disease characteristics (Hoehn and Yahr stage, MDS-UPDRS total score and Part III motor score), motor phenotype (based on Stebbin et al's algorithm), and levodopa equivalent daily dose (LEDD) were documented. RESULTS: Data are presented for 825 PD whose mean age at study was 63.7 ± 10.1 years, female sex-221 [26.8%] while median PD duration was 36 months. PD phenotypes included tremor-dominant 466 (56.5%), postural instability and gait disorder (PIGD) 259 (31.4%), and indeterminate 100 (12.1%). 82.6% were on treatment (median LEDD of 500 mg/24 hours). 804 (97.5%) endorsed at least 1 NMS. The median NMSS score was 26.0 while subscores for urinary and sexual function domains were significantly higher in males (P < 0.05). PIGD-PD had more frequent NMS and higher frequency of severe/very severe NMSS burden (P = 0.000 for both). Nocturia and fatigue were the most prevalent NMS overall and across motor subtypes. PIGD phenotype and total UPDRS scores were the independent determinants of NMSS scores (P = 0.000). CONCLUSION: The profile and burden of NMS, and association with motor subtype in our black African cohort is largely similar to descriptions from other populations.
Authors: Paul A Harris; Robert Taylor; Robert Thielke; Jonathon Payne; Nathaniel Gonzalez; Jose G Conde Journal: J Biomed Inform Date: 2008-09-30 Impact factor: 6.317
Authors: Glenn T Stebbins; Christopher G Goetz; David J Burn; Joseph Jankovic; Tien K Khoo; Barbara C Tilley Journal: Mov Disord Date: 2013-02-13 Impact factor: 10.338
Authors: Pablo Martinez-Martin; Cristian Falup Pecurariu; Per Odin; Jacobus J van Hilten; Angelo Antonini; Jose M Rojo-Abuin; Vanderci Borges; Claudia Trenkwalder; Dag Aarsland; David J Brooks; Kallol Ray Chaudhuri Journal: J Neurol Date: 2012-01-12 Impact factor: 4.849