Literature DB >> 2338142

Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus.

Y Hidaka1, K Sato, H Nakamura, J Kobayashi, Y Ohizumi, Y Shimonishi.   

Abstract

The three intramolecular disulfide linkages of geographutoxin I, a peptide neurotoxin isolated from the venom of the marine snail Conus geographus, were examined by a novel method for determination of the positions of disulfide linkages in peptides [(1989) Bull. Chem. Soc. Jp. 62, 1986-1994]. The disulfide bridges were found to be between Cys3 and Cys15, Cys4 and Cys20, and Cys21, indicating that geographutoxin I has a rigid conformation consisting of three loops stabilized by these three disulfide linkages.

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Year:  1990        PMID： 2338142     DOI： 10.1016/0014-5793(90)80756-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Novel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry.

Authors:  Tian Xue; Irene L Ennis; Kazuki Sato; Robert J French; Ronald A Li
Journal:  Biophys J       Date:  2003-10       Impact factor: 4.033

Review 2.  Using the deadly mu-conotoxins as probes of voltage-gated sodium channels.

Authors:  Ronald A Li; Gordon F Tomaselli
Journal:  Toxicon       Date:  2004-08       Impact factor: 3.033

3.  Distinct disulfide isomers of μ-conotoxins KIIIA and KIIIB block voltage-gated sodium channels.

Authors:  Keith K Khoo; Kallol Gupta; Brad R Green; Min-Min Zhang; Maren Watkins; Baldomero M Olivera; Padmanabhan Balaram; Doju Yoshikami; Grzegorz Bulaj; Raymond S Norton
Journal:  Biochemistry       Date:  2012-11-28       Impact factor: 3.162

4.  Mass spectrometric-based revision of the structure of a cysteine-rich peptide toxin with gamma-carboxyglutamic acid, TxVIIA, from the sea snail, Conus textile.

Authors:  T Nakamura; Z Yu; M Fainzilber; A L Burlingame
Journal:  Protein Sci       Date:  1996-03       Impact factor: 6.725

5.  Disulfide structures of highly bridged peptides: a new strategy for analysis.

Authors:  W R Gray
Journal:  Protein Sci       Date:  1993-10       Impact factor: 6.725

6.  Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site.

Authors:  M Chahine; J Sirois; P Marcotte; L Chen; R G Kallen
Journal:  Biophys J       Date:  1998-07       Impact factor: 4.033

7.  The Role of Individual Disulfide Bonds of μ-Conotoxin GIIIA in the Inhibition of NaV1.4.

Authors:  Penggang Han; Kang Wang; Xiandong Dai; Ying Cao; Shangyi Liu; Hui Jiang; Chongxu Fan; Wenjian Wu; Jisheng Chen
Journal:  Mar Drugs       Date:  2016-11-18       Impact factor: 5.118

Review 8.  Discovery, synthesis, and structure-activity relationships of conotoxins.

Authors:  Kalyana B Akondi; Markus Muttenthaler; Sébastien Dutertre; Quentin Kaas; David J Craik; Richard J Lewis; Paul F Alewood
Journal:  Chem Rev       Date:  2014-04-10       Impact factor: 60.622
  8 in total

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