Literature DB >> 15246758

Using the deadly mu-conotoxins as probes of voltage-gated sodium channels.

Ronald A Li1, Gordon F Tomaselli.   

Abstract

Mu-Conotoxins (mu-CTX) are potent Na channel inhibitory peptides isolated from the venom of the predatory marine snail Conus geographus. Mu-CTXs exert their biological action by physically occluding the ion-conducting pore of voltage-gated Na (Na(v)) channels with a 1:1 stoichiometry in an all-or-none fashion. This article reviews our current knowledge of the mechanism of mu-CTX and the associated structural and functional insights into its molecular target--Na(v) channels.

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Year:  2004        PMID： 15246758      PMCID： PMC2698010          DOI： 10.1016/j.toxicon.2004.03.028

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  30 in total

1.  Electrostatic distance geometry in a K+ channel vestibule.

Authors:  M Stocker; C Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1994-09-27       Impact factor: 11.205

2.  Pore-blocking toxins as probes of voltage-dependent channels.

Authors:  R J French; S C Dudley
Journal:  Methods Enzymol       Date:  1999       Impact factor: 1.600

3.  The structure of the potassium channel: molecular basis of K+ conduction and selectivity.

Authors:  D A Doyle; J Morais Cabral; R A Pfuetzner; A Kuo; J M Gulbis; S L Cohen; B T Chait; R MacKinnon
Journal:  Science       Date:  1998-04-03       Impact factor: 47.728

Review 4.  Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms.

Authors:  H A Fozzard; D A Hanck
Journal:  Physiol Rev       Date:  1996-07       Impact factor: 37.312

5.  Ion channels as enzymes: analogy or homology?

Authors:  E Marban; G F Tomaselli
Journal:  Trends Neurosci       Date:  1997-04       Impact factor: 13.837

6.  Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis.

Authors:  R A Li; R G Tsushima; R G Kallen; P H Backx
Journal:  Biophys J       Date:  1997-10       Impact factor: 4.033

7.  Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis.

Authors:  N S Chang; R J French; G M Lipkind; H A Fozzard; S Dudley
Journal:  Biochemistry       Date:  1998-03-31       Impact factor: 3.162

8.  Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus.

Authors:  Y Hidaka; K Sato; H Nakamura; J Kobayashi; Y Ohizumi; Y Shimonishi
Journal:  FEBS Lett       Date:  1990-05-07       Impact factor: 4.124

9.  Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels.

Authors:  J M Hill; P F Alewood; D J Craik
Journal:  Biochemistry       Date:  1996-07-09       Impact factor: 3.162

10.  Depth asymmetries of the pore-lining segments of the Na+ channel revealed by cysteine mutagenesis.

Authors:  N Chiamvimonvat; M T Pérez-García; R Ranjan; E Marban; G F Tomaselli
Journal:  Neuron       Date:  1996-05       Impact factor: 17.173
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  12 in total

Review 1.  HCN-encoded pacemaker channels: from physiology and biophysics to bioengineering.

Authors:  C-W Siu; D K Lieu; R A Li
Journal:  J Membr Biol       Date:  2007-06-08       Impact factor: 1.843

Review 2.  Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity.

Authors:  Brad R Green; Grzegorz Bulaj; Raymond S Norton
Journal:  Future Med Chem       Date:  2014-10       Impact factor: 3.808

3.  Structural plasticity of mini-M conotoxins - expression of all mini-M subtypes by Conus regius.

Authors:  Aldo Franco; Sanaz Dovell; Carolina Möller; Meghan Grandal; Evan Clark; Frank Marí
Journal:  FEBS J       Date:  2018-01-28       Impact factor: 5.542

4.  Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB.

Authors:  O Knapp; S T Nevin; T Yasuda; N Lawrence; R J Lewis; D J Adams
Journal:  Br J Pharmacol       Date:  2012-08       Impact factor: 8.739

5.  A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors.

Authors:  Philippe Favreau; Evelyne Benoit; Henry G Hocking; Ludovic Carlier; Dieter D' hoedt; Enrico Leipold; René Markgraf; Sébastien Schlumberger; Marco A Córdova; Hubert Gaertner; Marianne Paolini-Bertrand; Oliver Hartley; Jan Tytgat; Stefan H Heinemann; Daniel Bertrand; Rolf Boelens; Reto Stöcklin; Jordi Molgó
Journal:  Br J Pharmacol       Date:  2012-07       Impact factor: 8.739

6.  Mechanism of Ion Permeation in Mammalian Voltage-Gated Sodium Channels.

Authors:  Somayeh Mahdavi; Serdar Kuyucak
Journal:  PLoS One       Date:  2015-08-14       Impact factor: 3.240

Review 7.  Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition.

Authors:  Nehan R Munasinghe; MacDonald J Christie
Journal:  Toxins (Basel)       Date:  2015-12-10       Impact factor: 4.546

8.  Molecular dynamics study of binding of µ-conotoxin GIIIA to the voltage-gated sodium channel Na(v)1.4.

Authors:  Somayeh Mahdavi; Serdar Kuyucak
Journal:  PLoS One       Date:  2014-08-18       Impact factor: 3.240

9.  Systematic study of binding of μ-conotoxins to the sodium channel NaV1.4.

Authors:  Somayeh Mahdavi; Serdar Kuyucak
Journal:  Toxins (Basel)       Date:  2014-12-18       Impact factor: 4.546

Review 10.  Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery.

Authors:  Bingmiao Gao; Chao Peng; Jiaan Yang; Yunhai Yi; Junqing Zhang; Qiong Shi
Journal:  Toxins (Basel)       Date:  2017-12-07       Impact factor: 4.546
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