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Literature DB >> 24720541

Discovery, synthesis, and structure-activity relationships of conotoxins.

Kalyana B Akondi¹, Markus Muttenthaler, Sébastien Dutertre, Quentin Kaas, David J Craik, Richard J Lewis, Paul F Alewood.

Abstract

Entities: Chemical

Mesh：

Substances：
Conotoxins

Year: 2014 PMID： 24720541 PMCID： PMC7610532 DOI： 10.1021/cr400401e

Source DB: PubMed Journal: Chem Rev ISSN： 0009-2665 Impact factor: 60.622

× No keyword cloud information.

289 in total

1. Three-dimensional solution structure of omega-conotoxin TxVII, an L-type calcium channel blocker.

Authors: K Kobayashi; T Sasaki; K Sato; T Kohno
Journal: Biochemistry Date: 2000-12-05 Impact factor: 3.162

2. Extensive and continuous duplication facilitates rapid evolution and diversification of gene families.

Authors: Dan Chang; Thomas F Duda
Journal: Mol Biol Evol Date: 2012-02-15 Impact factor: 16.240

3. Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding.

Authors: Aline Dantas de Araujo; Brid Callaghan; Simon T Nevin; Norelle L Daly; David J Craik; Melissa Moretta; Gene Hopping; Macdonald J Christie; David J Adams; Paul F Alewood
Journal: Angew Chem Int Ed Engl Date: 2011-05-31 Impact factor: 15.336

4. New mollusc-specific alpha-conotoxins block Aplysia neuronal acetylcholine receptors.

Authors: M Fainzilber; A Hasson; R Oren; A L Burlingame; D Gordon; M E Spira; E Zlotkin
Journal: Biochemistry Date: 1994-08-16 Impact factor: 3.162

5. Modulating oxytocin activity and plasma stability by disulfide bond engineering.

Authors: Markus Muttenthaler; Asa Andersson; Aline D de Araujo; Zoltan Dekan; Richard J Lewis; Paul F Alewood
Journal: J Med Chem Date: 2010-11-30 Impact factor: 7.446

Review 6. Speciation of cone snails and interspecific hyperdivergence of their venom peptides. Potential evolutionary significance of introns.

Authors: B M Olivera; C Walker; G E Cartier; D Hooper; A D Santos; R Schoenfeld; R Shetty; M Watkins; P Bandyopadhyay; D R Hillyard
Journal: Ann N Y Acad Sci Date: 1999-05-18 Impact factor: 5.691

Review 7. Selenocysteine.

Authors: T C Stadtman
Journal: Annu Rev Biochem Date: 1996 Impact factor: 23.643

8. Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels.

Authors: K Sato; N G Park; T Kohno; T Maeda; J I Kim; R Kato; M Takahashi
Journal: Biochem Biophys Res Commun Date: 1993-08-16 Impact factor: 3.575

Review 9. Alpha9 nicotinic acetylcholine receptors and the treatment of pain.

Authors: J Michael McIntosh; Nathan Absalom; Mary Chebib; Ana Belén Elgoyhen; Michelle Vincler
Journal: Biochem Pharmacol Date: 2009-05-27 Impact factor: 5.858

10. Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations.

Authors: Rilei Yu; David J Craik; Quentin Kaas
Journal: PLoS Comput Biol Date: 2011-03-03 Impact factor: 4.475

87 in total

1. Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.

Authors: Sulan Luo; Dongting Zhangsun; Peta J Harvey; Quentin Kaas; Yong Wu; Xiaopeng Zhu; Yuanyan Hu; Xiaodan Li; Victor I Tsetlin; Sean Christensen; Haylie K Romero; Melissa McIntyre; Cheryl Dowell; James C Baxter; Keith S Elmslie; David J Craik; J Michael McIntosh
Journal: Proc Natl Acad Sci U S A Date: 2015-07-13 Impact factor: 11.205

Review 2. Trends in peptide drug discovery.

Authors: Markus Muttenthaler; Glenn F King; David J Adams; Paul F Alewood
Journal: Nat Rev Drug Discov Date: 2021-02-03 Impact factor: 84.694

Review 3. α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition.

Authors: Hartmut Cuny; Rilei Yu; Han-Shen Tae; Shiva N Kompella; David J Adams
Journal: Br J Pharmacol Date: 2017-06-11 Impact factor: 8.739

Discovery, synthesis, and structure-activity relationships of conotoxins.

1. Three-dimensional solution structure of omega-conotoxin TxVII, an L-type calcium channel blocker.

2. Extensive and continuous duplication facilitates rapid evolution and diversification of gene families.

3. Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding.

4. New mollusc-specific alpha-conotoxins block Aplysia neuronal acetylcholine receptors.

5. Modulating oxytocin activity and plasma stability by disulfide bond engineering.

Review 6. Speciation of cone snails and interspecific hyperdivergence of their venom peptides. Potential evolutionary significance of introns.

Review 7. Selenocysteine.

8. Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels.

Review 9. Alpha9 nicotinic acetylcholine receptors and the treatment of pain.

10. Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations.

1. Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.

Review 2. Trends in peptide drug discovery.

Review 3. α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition.

Review 4. Hormone-like conopeptides - new tools for pharmaceutical design.

5. Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer.

Review 6. Chemistry and Enzymology of Disulfide Cross-Linking in Proteins.

7. Structural plasticity of mini-M conotoxins - expression of all mini-M subtypes by Conus regius.

Review 8. Recent advances in the biosynthesis of RiPPs from multicore-containing precursor peptides.

9. α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors.

10. On-resin strategy to label α-conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe.