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Literature DB >> 23379618

Noninvasive and targeted drug delivery to the brain using focused ultrasound.

Abstract

Brain diseases are notoriously difficult to treat due to the presence of the blood-brain barrier (BBB). Here, we review the development of focused ultrasound (FUS) as a noninvasive method for BBB disruption, aiding in drug delivery to the brain. FUS can be applied through the skull to a targeted region in the brain. When combined with microbubbles, FUS causes localized and reversible disruption of the BBB. The cellular mechanisms of BBB disruption are presented. Several therapeutic agents have been delivered to the brain resulting in significant improvements in pathology in models of glioblastoma and Alzheimer's disease. The requirements for clinical translation of FUS will be discussed.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2013 PMID： 23379618 PMCID： PMC3629738 DOI： 10.1021/cn300191b

Source DB: PubMed Journal: ACS Chem Neurosci ISSN： 1948-7193 Impact factor: 4.418

80 in total

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Authors: Kullervo Hynynen; Nathan McDannold; Nickolai A Sheikov; Ferenc A Jolesz; Natalia Vykhodtseva
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Journal: J Cereb Blood Flow Metab Date: 2016-01-01 Impact factor: 6.200

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6. Gene Silencing in the Right Place at the Right Time.

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