Literature DB >> 23377963

Effects of Canavalia lectins on acute inflammation in sensitized and non-sensitized rats.

Nilson Vieira Pinto1, Benildo Sousa Cavada, Lucas Ferreira Brito, Ronniery Ilario Pereira, Mayara Torquato Lima da Silva, Rondinelle Ribeiro Castro, Alana de Freitas Pires, Ana Maria Sampaio Assreuy.   

Abstract

The anti-inflammatory activity of Canavalia seed lectins (Canavalia gladiata [CGL], Canavalia maritima [ConM] and Canavalia brasiliensis [ConBr]) was evaluated by intravenous administration in rats. In non-sensitized rats, cellular edema elicited by carrageenan was reduced (45-51 %) by ConM and (44-59 %) by CGL. Osmotic edema elicited by dextran was reduced by ConM and CGL in 27 % and 29 %. ConM and CGL reduced the edema elicited by L-arginine in 53 % and that of prostaglandin E2 in 48 % and 36 %. Leukocyte migration elicited by carrageenan was reduced in 49 % by ConM and in 55 % by CGL (attenuated in 4× by glucose) and peritoneal TNF-α content in 82 %. In rats sensitized, ConM inhibited the paw edema and leukocyte migration elicited by ovalbumin in 34 % and 70 %. ConM and CGL are anti-inflammatory, mainly in cellular events mediated by prostaglandin E₂, nitric oxide and TNF-α in non-sensitized rats. However, only ConM is anti-inflammatory in sensitized rats. CGL effect involves the lectin domain.

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Year:  2013        PMID： 23377963     DOI： 10.1007/s10753-013-9596-0

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  34 in total

1.  The role of weak protein-protein interactions in multivalent lectin-carbohydrate binding: crystal structure of cross-linked FRIL.

Authors:  T W Hamelryck; J G Moore; M J Chrispeels; R Loris; L Wyns
Journal:  J Mol Biol       Date:  2000-06-16       Impact factor: 5.469

2.  Structural basis for both pro- and anti-inflammatory response induced by mannose-specific legume lectin from Cymbosema roseum.

Authors:  Bruno A M Rocha; Plinio Delatorre; Taianá M Oliveira; Raquel G Benevides; Alana F Pires; Albertina A S Sousa; Luis A G Souza; Ana Maria S Assreuy; Henri Debray; Walter F de Azevedo; Alexandre H Sampaio; Benildo S Cavada
Journal:  Biochimie       Date:  2011-01-26       Impact factor: 4.079

3.  Crystallization and preliminary X-ray diffraction analysis of the lectin from Canavalia gladiata seeds.

Authors:  Frederico B M B Moreno; Plínio Delatorre; Beatriz T Freitas; Bruno A M Rocha; Emmanuel P Souza; Felipe Facó; Fernanda Canduri; André L H Cardoso; Valder N Freire; José L Lima Filho; Alexandre H Sampaio; Juan J Calvete; Walter F De Azevedo; Benildo S Cavada
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2004-07-21

4.  Acute and chronic toxicological studies of Ajuga iva in experimental animals.

Authors:  Jaouad El Hilaly; Zafar H Israili; Badiâa Lyoussi
Journal:  J Ethnopharmacol       Date:  2004-03       Impact factor: 4.360

5.  Expression of adhesion molecules and effect of disodium cromoglycate treatment in asthmatics.

Authors:  E Jahnová; M Horváthová; F Gazdík
Journal:  Physiol Res       Date:  1998       Impact factor: 1.881

Review 6.  The neutrophil, a professional killer of bacteria, may be controlled by T cells.

Authors:  P A Campbell
Journal:  Clin Exp Immunol       Date:  1990-02       Impact factor: 4.330

7.  Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins.

Authors:  Plínio Delatorre; Bruno A M Rocha; Carlos A A Gadelha; Tatiane Santi-Gadelha; João B Cajazeiras; Emmanuel P Souza; Kyria S Nascimento; Valder N Freire; Alexandre H Sampaio; Walter F Azevedo; Benildo S Cavada
Journal:  J Struct Biol       Date:  2006-04-21       Impact factor: 2.867

8.  Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: new insights into the understanding of the structure-biological activity relationship in legume lectins.

Authors:  Gustavo Arruda Bezerra; Taianá Maia Oliveira; Frederico Bruno Mendes Batista Moreno; Emmanuel Prata de Souza; Bruno Anderson Matias da Rocha; Raquel Guimarães Benevides; Plínio Delatorre; Walter Filgueira de Azevedo; Benildo Sousa Cavada
Journal:  J Struct Biol       Date:  2007-08-16       Impact factor: 2.867

9.  Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production.

Authors:  Marcelo H Napimoga; Benildo S Cavada; Nylane M N Alencar; Mário L Mota; Flávio S Bittencourt; José C Alves-Filho; Renata Grespan; Reginaldo B Gonçalves; Juliana T Clemente-Napimoga; Andressa de Freitas; Carlos A Parada; Sérgio H Ferreira; Fernando Q Cunha
Journal:  Int Immunopharmacol       Date:  2007-03-05       Impact factor: 4.932

10.  The pharmacological profile of ovalbumin-induced paw oedema in rats.

Authors:  R F G Feitosa; G B Melcíades; A M S Assreuy; M F G Rocha; R A Ribeiro; A A M Lima
Journal:  Mediators Inflamm       Date:  2002-06       Impact factor: 4.711
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  3 in total

1.  Role of Mast Cells and C-Sensory Fibers in Concanavalin A-Induced Paw Edema in Two Rat Strains.

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Journal:  Inflammation       Date:  2015-08       Impact factor: 4.092

2.  The anti-inflamatory effect of Andira anthelmia lectin in rats involves inhibition of the prostanoid pathway, TNF-α and lectin domain.

Authors:  Francisco Lucas Faustino do Nascimento; Alana de Freitas Pires; Mário Rogério Lima Mota; Pedro Henrique Chaves Isaias; Diego Freitas de Araujo; Maria Gleiciane de Queiroz Martins; Cleane Gomes Moreira; João Batista Cajazeiras; Benildo Sousa Cavada; Kyria Santiago do Nascimento; Ana Maria Sampaio Assreuy
Journal:  Mol Biol Rep       Date:  2022-07-26       Impact factor: 2.742

3.  A novel N-acetyl-glucosamine lectin of Lonchocarpus araripensis attenuates acute cellular inflammation in mice.

Authors:  Alana F Pires; Natália V F C Rodrigues; Pedro Marcos G Soares; Ronaldo de Albuquerque Ribeiro; Karoline S Aragão; Márcia M Marinho; Mayara T L da Silva; Benildo S Cavada; Ana Maria S Assreuy
Journal:  Inflamm Res       Date:  2015-11-06       Impact factor: 4.575
  3 in total

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