Literature DB >> 3841121

PD 118,576: a new antitumor macrolide antibiotic.

J H Wilton, G C Hokanson, J C French.   

Abstract

The isolation and properties of PD 118,576, a new cytotoxic antibiotic obtained from the culture broth of a Streptomyces sp., are described. The structure of this compound was established by spectral analyses of the parent compound and its tri-O-acetyl derivative. PD 118,576 proved to be related to the bafilomycins and therefore is a new member of this recently discovered family of macrolide antibiotics.

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Year:  1985        PMID: 3841121     DOI: 10.7164/antibiotics.38.1449

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  6 in total

1.  Complete elucidation of the late steps of bafilomycin biosynthesis in Streptomyces lohii.

Authors:  Zhong Li; Lei Du; Wei Zhang; Xingwang Zhang; Yuanyuan Jiang; Kun Liu; Ping Men; Huifang Xu; Jeffrey L Fortman; David H Sherman; Bing Yu; Song Gao; Shengying Li
Journal:  J Biol Chem       Date:  2017-03-14       Impact factor: 5.157

2.  Bafilomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209.

Authors:  Zhiguo Yu; Li-Xing Zhao; Cheng-Lin Jiang; Yanwen Duan; Lily Wong; Kristopher C Carver; Linda A Schuler; Ben Shen
Journal:  J Antibiot (Tokyo)       Date:  2010-11-24       Impact factor: 2.649

3.  Increased valinomycin production in mutants of Streptomyces sp. M10 defective in bafilomycin biosynthesis and branched-chain α-keto acid dehydrogenase complex expression.

Authors:  Dong Wan Lee; Bee Gek Ng; Beom Seok Kim
Journal:  J Ind Microbiol Biotechnol       Date:  2015-09-03       Impact factor: 3.346

4.  Characterization of the bafilomycin biosynthetic gene cluster from Streptomyces lohii.

Authors:  Wei Zhang; Jeffrey L Fortman; Jacob C Carlson; Jinyong Yan; Yi Liu; Fali Bai; Wenna Guan; Junyong Jia; Teatulohi Matainaho; David H Sherman; Shengying Li
Journal:  Chembiochem       Date:  2013-01-29       Impact factor: 3.164

5.  Biosynthesis of 2-amino-3-hydroxycyclopent-2-enone moiety of bafilomycin in Kitasatospora cheerisanensis KCTC2395.

Authors:  Nguyen Phan Kieu Hanh; Jae Yoon Hwang; Hye Ryeung Oh; Geum Jin Kim; Hyukjae Choi; Doo Hyun Nam
Journal:  J Microbiol       Date:  2018-07-25       Impact factor: 3.422

6.  Engineering Bafilomycin High-Producers by Manipulating Regulatory and Biosynthetic Genes in the Marine Bacterium Streptomyces lohii.

Authors:  Zhong Li; Shuai Li; Lei Du; Xingwang Zhang; Yuanyuan Jiang; Wenhua Liu; Wei Zhang; Shengying Li
Journal:  Mar Drugs       Date:  2021-01-11       Impact factor: 5.118

  6 in total

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