Literature DB >> 23362046

Flexibility and reactivity in promiscuous enzymes.

Pietro Gatti-Lafranconi1, Florian Hollfelder.   

Abstract

Best of both worlds: The interplay of active site reactivity and the dynamic character of proteins allows enzymes to be promiscuous and--sometimes--remarkably efficient at the same time. This review analyses the roles structural flexibility and chemical reactivity play in the catalytic mechanism of selected enzymes.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2013        PMID： 23362046     DOI： 10.1002/cbic.201200628

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  14 in total

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Authors:  Jun Zhang; Ankanahalli N Nanjaraj Urs; Lianyun Lin; Yan Zhou; Yiling Hu; Gaoqun Hua; Qiang Gao; Zhiguang Yuchi; Yan Zhang
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2019-02-21       Impact factor: 1.056

Review 2.  How enzyme promiscuity and horizontal gene transfer contribute to metabolic innovation.

Authors:  Margaret E Glasner; Dat P Truong; Benjamin C Morse
Journal:  FEBS J       Date:  2020-01-10       Impact factor: 5.542

Review 3.  A mechanistic view of enzyme evolution.

Authors:  Gloria Yang; Charlotte M Miton; Nobuhiko Tokuriki
Journal:  Protein Sci       Date:  2020-08       Impact factor: 6.725

Review 4.  Engineering polyketide synthases and nonribosomal peptide synthetases.

Authors:  Gavin J Williams
Journal:  Curr Opin Struct Biol       Date:  2013-07-06       Impact factor: 6.809

Review 5.  Detecting enzyme activities with exogenous MRI contrast agents.

Authors:  Dina V Hingorani; Byunghee Yoo; Adam S Bernstein; Mark D Pagel
Journal:  Chemistry       Date:  2014-07-02       Impact factor: 5.236

Review 6.  Opportunities for merging chemical and biological synthesis.

Authors:  Stephen Wallace; Emily P Balskus
Journal:  Curr Opin Biotechnol       Date:  2014-04-18       Impact factor: 9.740

Review 7.  The Classification and Evolution of Enzyme Function.

Authors:  Sergio Martínez Cuesta; Syed Asad Rahman; Nicholas Furnham; Janet M Thornton
Journal:  Biophys J       Date:  2015-05-15       Impact factor: 4.033

8.  A highly versatile fungal glucosyltransferase for specific production of quercetin-7-O-β-D-glucoside and quercetin-3-O-β-D-glucoside in different hosts.

Authors:  Jie Ren; Wenzhu Tang; Caleb Don Barton; Owen M Price; Mark Wayne Mortensen; Alexandra Phillips; Banner Wald; Simon Elgin Hulme; Logan Powell Stanley; Joan Hevel; Jixun Zhan
Journal:  Appl Microbiol Biotechnol       Date:  2021-12-07       Impact factor: 4.813

Review 9.  A decade and a half of protein intrinsic disorder: biology still waits for physics.

Authors:  Vladimir N Uversky
Journal:  Protein Sci       Date:  2013-04-29       Impact factor: 6.725

10.  Modeling catalytic promiscuity in the alkaline phosphatase superfamily.

Authors:  Fernanda Duarte; Beat Anton Amrein; Shina Caroline Lynn Kamerlin
Journal:  Phys Chem Chem Phys       Date:  2013-06-03       Impact factor: 3.676
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