| Literature DB >> 23353055 |
Xiaojing Meng1, Chunqing Cai, Jiguo Wu, Shaoxi Cai, Changsheng Ye, Haiyang Chen, Zhengduo Yang, Hongqiang Zeng, Qiang Shen, Fei Zou.
Abstract
Metastasis is an inherent feature of breast cancer and transient receptor potential (TRP) channels were found to be potentially implicated in this process. Particularly, TRPM7 may regulate cell motility. We therefore examined the expression of TRPM7 mRNA in the Oncomine database and found that TRPM7 is correlated to metastasis and invasive breast cancer. Silencing TRPM7 with RNA interference resulted in a significant decrease in migration and invasion capability of MDA-MB-435 breast cancer cells, and phosphorylation levels of Src and MAPK but not AKT. Our results suggest that TRPM7 regulates migration and invasion of metastatic breast cancer cells via MAPK pathway.Entities:
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Year: 2013 PMID： 23353055 DOI： 10.1016/j.canlet.2013.01.031
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679