Literature DB >> 23342967

Carbon monoxide form of PEGylated hemoglobin protects myocardium against ischemia/reperfusion injury in diabetic and normal mice.

Radha Ananthakrishnan1, Qing Li, Karen M O'Shea, Nosirudeen Quadri, Lingjie Wang, Abraham Abuchowski, Ann Marie Schmidt, Ravichandran Ramasamy.   

Abstract

We investigated the pre-clinical utility of carbon monoxide form of PEGylated hemoglobin (PEG-Hb also named SANGUINATE(™)) in myocardial infarction (MI) and in particular the response of diabetic tissues to superimposed ischemia/reperfusion injury. SANGUINATE(™) was evaluated in diabetic and normal mice subjected to 30 min of coronary artery ligation followed by either 48 h or 28 days of reperfusion. Our results demonstrate that SANGUINATE(™) was effective in reducing infarct size when administered either prior to left anterior descending coronary artery (LAD) occlusion or during reperfusion. This finding is an important step in exploring the efficacy of a pharmacoinvasive strategy using SANGUINATE(™) in patients with acute coronary syndromes.

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Year:  2013        PMID： 23342967     DOI： 10.3109/21691401.2012.762370

Source DB:  PubMed          Journal:  Artif Cells Nanomed Biotechnol        ISSN： 2169-1401            Impact factor:   5.678


  11 in total

1.  SANGUINATE™ (PEGylated Carboxyhemoglobin Bovine) Improves Cerebral Blood Flow to Vulnerable Brain Regions at Risk of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage.

Authors:  Rajat Dhar; Hemant Misra; Michael N Diringer
Journal:  Neurocrit Care       Date:  2017-12       Impact factor: 3.210

2.  2017 Military Supplement: Hemoglobin-based Oxygen Carriers: Current State-of-the-Art and Novel Molecules.

Authors:  Anirban Sen Gupta
Journal:  Shock       Date:  2017-09-29       Impact factor: 3.454

3.  Scalable production and complete biophysical characterization of poly(ethylene glycol) surface conjugated liposome encapsulated hemoglobin (PEG-LEH).

Authors:  Uddyalok Banerjee; Savannah Wolfe; Quintin O'Boyle; Clayton Cuddington; Andre F Palmer
Journal:  PLoS One       Date:  2022-07-08       Impact factor: 3.752

4.  PEGylation of αα-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG αα-Hbs.

Authors:  Fantao Meng; Amy G Tsai; Marcos Intaglietta; Seetharama A Acharya
Journal:  Artif Cells Nanomed Biotechnol       Date:  2014-03-06       Impact factor: 5.678

5.  Investigational use of PEGylated carboxyhemoglobin bovine in a Jehovah's Witness with hemorrhagic shock.

Authors:  Robert A DeSimone; David A Berlin; Scott T Avecilla; Cheryl A Goss
Journal:  Transfusion       Date:  2018-09-11       Impact factor: 3.157

6.  A Phase Ib open label, randomized, safety study of SANGUINATE™ in patients with sickle cell anemia.

Authors:  Hemant Misra; James Bainbridge; John Berryman; Abraham Abuchowski; Kenneth Mauricio Galvez; Luis Fernando Uribe; Angel Luis Hernandez; Nestor Rodolfo Sosa
Journal:  Rev Bras Hematol Hemoter       Date:  2016-10-20

Review 7.  Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers.

Authors:  Kazuaki Taguchi; Keishi Yamasaki; Toru Maruyama; Masaki Otagiri
Journal:  J Funct Biomater       Date:  2017-03-18

Review 8.  Potential Use of Biological Proteins for Liver Failure Therapy.

Authors:  Kazuaki Taguchi; Keishi Yamasaki; Hakaru Seo; Masaki Otagiri
Journal:  Pharmaceutics       Date:  2015-08-31       Impact factor: 6.321

9.  Aldose reductase modulates acute activation of mesenchymal markers via the β-catenin pathway during cardiac ischemia-reperfusion.

Authors:  Devi Thiagarajan; Karen O' Shea; Gopalkrishna Sreejit; Radha Ananthakrishnan; Nosirudeen Quadri; Qing Li; Ann Marie Schmidt; Kenneth Gabbay; Ravichandran Ramasamy
Journal:  PLoS One       Date:  2017-11-30       Impact factor: 3.240

10.  PEGylated carboxyhemoglobin bovine (SANGUINATE) ameliorates myocardial infarction in a rat model.

Authors:  Akira T Kawaguchi; Amankeldi A Salybekov; Mariko Yamano; Hiroaki Kitagishi; Kaori Sekine; Tetsuro Tamaki
Journal:  Artif Organs       Date:  2018-12       Impact factor: 3.094
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